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Fig. 5 | Cancer Communications

Fig. 5

From: Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis

Fig. 5

PGK1 pS203 and PDHK1 pT338 levels increased from normal to tumor tissues in human cancers. PGK1 pS203 and PDHK1 pT338 levels in normal tissues, early-stage tumor tissues, and advanced tumor tissues were compared using immunohistochemical staining. Representative images are shown. a Breast carcinoma (BRCA). b Liver hepatocellular carcinoma (LIHC). c Lung adenocarcinoma (LUAD). d Stomach adenocarcinoma (STAD). e Esophageal carcinoma (ESCA). *P < 0.05, **P < 0.01, ***P < 0.001 (2-tailed). PGK1 pS203 phosphorylated phosphoglycerate kinase 1 (PGK1) S203, PDHK1 pT338 phosphorylated phosphorylate pyruvate dehydrogenase kinase 1 (PDHK1) T338, HE hematoxylin–eosin staining

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