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Table 4 Unconditional logistic regression analyses assessing associations of gene polymorphisms with HFS
| Gene | SNP | Genetic model | Genotype | Patients without HFS [cases (%)] | Patients with HFS [cases (%)] | OR (95% CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|---|
| TYMS | rs2606241 | Codominant | GG | 34 (22.8) | 44 (22.8) | 1.00 | 0.012 | 449.7 | 476.4 |
| GT | 69 (46.3) | 113 (58.5) | 1.27 (0.73–2.23) | ||||||
| TT | 44 (29.5) | 33 (17.1) | 0.55 (0.28–1.06) | ||||||
| Dominant | GG | 34 (22.8) | 44 (22.8) | 1.00 | 0.960 | 456.5 | 479.4 | ||
| GT + TT | 113 (75.8) | 146 (75.6) | 0.99 (0.58–1.68) | ||||||
| Recessive | GG + GT | 103 (69.1) | 157 (81.3) | 1.00 | 0.004 | 448.4 | 471.3 | ||
| TT | 44 (29.5) | 33 (17.1) | 0.46 (0.27–0.79) | ||||||
| Overdominant | GG + TT | 78 (52.3) | 77 (39.9) | 1.00 | 0.018 | 450.9 | 473.8 | ||
| GT | 69 (46.3) | 113 (58.5) | 1.72 (1.10–2.70) | ||||||
| Log-additive | NA | NA | NA | 0.74 (0.53–1.03) | 0.071 | 453.3 | 476.2 | ||
| rs2853741 | Codominant | TT | 48 (32.2) | 38 (19.9) | 1.00 | 0.012 | 449.6 | 476.4 | |
| CT | 68 (45.6) | 113 (58.5) | 2.25 (1.31–3.87) | ||||||
| CC | 31 (20.8) | 39 (20.2) | 1.71 (0.81–3.31) | ||||||
| Dominant | TT | 48 (32.2) | 38 (19.9) | 1.00 | 0.005 | 448.5 | 471.4 | ||
| TC + CC | 99 (66.4) | 152 (78.8) | 2.09 (1.25–3.49) | ||||||
| Recessive | TT + TC | 116 (77.9) | 151 (78.2) | 1.00 | 0.950 | 456.4 | 479.4 | ||
| CC | 31 (20.8) | 39 (20.2) | 0.98 (0.57–1.70) | ||||||
| Overdominant | TT + CC | 79 (53.0) | 77 (38.9) | 1.00 | 0.012 | 450.1 | 473.1 | ||
| TC | 68 (45.6) | 113 (58.5) | 1.77 (1.13–2.77) | ||||||
| Log-additive | NA | NA | NA | 1.35 (0.97–1.88) | 0.075 | 453.3 | 476.2 | ||
| MTHFR | rs4846048 | NA | AA | 115 (77.2) | 165 (85.5) | 1.00 | 0.042 | 453.7 | 476.7 |
| AG | 33 (22.1) | 25 (13.0) | 0.54 (0.30–0.98) | ||||||
| rs3737964 | NA | GG | 113 (75.8) | 165 (85.5) | 1.00 | 0.038 | 458.8 | 470.3 | |
| AG | 33 (22.1) | 25 (13.0) | 0.54 (0.31–0.97) |
