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Table 4 Unconditional logistic regression analyses assessing associations of gene polymorphisms with HFS

From: Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer

Gene SNP Genetic model Genotype Patients without HFS [cases (%)] Patients with HFS [cases (%)] OR (95% CI) P value AIC BIC
TYMS rs2606241 Codominant GG 34 (22.8) 44 (22.8) 1.00 0.012 449.7 476.4
GT 69 (46.3) 113 (58.5) 1.27 (0.73–2.23)
TT 44 (29.5) 33 (17.1) 0.55 (0.28–1.06)
Dominant GG 34 (22.8) 44 (22.8) 1.00 0.960 456.5 479.4
GT + TT 113 (75.8) 146 (75.6) 0.99 (0.58–1.68)
Recessive GG + GT 103 (69.1) 157 (81.3) 1.00 0.004 448.4 471.3
TT 44 (29.5) 33 (17.1) 0.46 (0.27–0.79)
Overdominant GG + TT 78 (52.3) 77 (39.9) 1.00 0.018 450.9 473.8
GT 69 (46.3) 113 (58.5) 1.72 (1.10–2.70)
Log-additive NA NA NA 0.74 (0.53–1.03) 0.071 453.3 476.2
rs2853741 Codominant TT 48 (32.2) 38 (19.9) 1.00 0.012 449.6 476.4
CT 68 (45.6) 113 (58.5) 2.25 (1.31–3.87)
CC 31 (20.8) 39 (20.2) 1.71 (0.81–3.31)
Dominant TT 48 (32.2) 38 (19.9) 1.00 0.005 448.5 471.4
TC + CC 99 (66.4) 152 (78.8) 2.09 (1.25–3.49)
Recessive TT + TC 116 (77.9) 151 (78.2) 1.00 0.950 456.4 479.4
CC 31 (20.8) 39 (20.2) 0.98 (0.57–1.70)
Overdominant TT + CC 79 (53.0) 77 (38.9) 1.00 0.012 450.1 473.1
TC 68 (45.6) 113 (58.5) 1.77 (1.13–2.77)
Log-additive NA NA NA 1.35 (0.97–1.88) 0.075 453.3 476.2
MTHFR rs4846048 NA AA 115 (77.2) 165 (85.5) 1.00 0.042 453.7 476.7
AG 33 (22.1) 25 (13.0) 0.54 (0.30–0.98)
rs3737964 NA GG 113 (75.8) 165 (85.5) 1.00 0.038 458.8 470.3
AG 33 (22.1) 25 (13.0) 0.54 (0.31–0.97)
  1. The lower the AIC and BIC values, the more accurate the model
  2. HFS hand-food syndrome, OR odds ratio, CI confidence interval, AIC Akaike’s information criterion, BIC Bayes information criterion, NA not applicable