|
Gene
|
SNP
|
Genetic model
|
Genotype
|
Patients without HFS [cases (%)]
|
Patients with HFS [cases (%)]
|
OR (95% CI)
|
P value
|
AIC
|
BIC
|
|---|
|
TYMS
|
rs2606241
|
Codominant
|
GG
|
34 (22.8)
|
44 (22.8)
|
1.00
|
0.012
|
449.7
|
476.4
|
|
GT
|
69 (46.3)
|
113 (58.5)
|
1.27 (0.73–2.23)
|
|
TT
|
44 (29.5)
|
33 (17.1)
|
0.55 (0.28–1.06)
|
|
Dominant
|
GG
|
34 (22.8)
|
44 (22.8)
|
1.00
|
0.960
|
456.5
|
479.4
|
|
GT + TT
|
113 (75.8)
|
146 (75.6)
|
0.99 (0.58–1.68)
|
|
Recessive
|
GG + GT
|
103 (69.1)
|
157 (81.3)
|
1.00
|
0.004
|
448.4
|
471.3
|
|
TT
|
44 (29.5)
|
33 (17.1)
|
0.46 (0.27–0.79)
|
|
Overdominant
|
GG + TT
|
78 (52.3)
|
77 (39.9)
|
1.00
|
0.018
|
450.9
|
473.8
|
|
GT
|
69 (46.3)
|
113 (58.5)
|
1.72 (1.10–2.70)
|
|
Log-additive
|
NA
|
NA
|
NA
|
0.74 (0.53–1.03)
|
0.071
|
453.3
|
476.2
|
|
rs2853741
|
Codominant
|
TT
|
48 (32.2)
|
38 (19.9)
|
1.00
|
0.012
|
449.6
|
476.4
|
|
CT
|
68 (45.6)
|
113 (58.5)
|
2.25 (1.31–3.87)
|
|
CC
|
31 (20.8)
|
39 (20.2)
|
1.71 (0.81–3.31)
|
|
Dominant
|
TT
|
48 (32.2)
|
38 (19.9)
|
1.00
|
0.005
|
448.5
|
471.4
|
|
TC + CC
|
99 (66.4)
|
152 (78.8)
|
2.09 (1.25–3.49)
|
|
Recessive
|
TT + TC
|
116 (77.9)
|
151 (78.2)
|
1.00
|
0.950
|
456.4
|
479.4
|
|
CC
|
31 (20.8)
|
39 (20.2)
|
0.98 (0.57–1.70)
|
|
Overdominant
|
TT + CC
|
79 (53.0)
|
77 (38.9)
|
1.00
|
0.012
|
450.1
|
473.1
|
|
TC
|
68 (45.6)
|
113 (58.5)
|
1.77 (1.13–2.77)
|
|
Log-additive
|
NA
|
NA
|
NA
|
1.35 (0.97–1.88)
|
0.075
|
453.3
|
476.2
|
|
MTHFR
|
rs4846048
|
NA
|
AA
|
115 (77.2)
|
165 (85.5)
|
1.00
|
0.042
|
453.7
|
476.7
|
|
AG
|
33 (22.1)
|
25 (13.0)
|
0.54 (0.30–0.98)
|
|
rs3737964
|
NA
|
GG
|
113 (75.8)
|
165 (85.5)
|
1.00
|
0.038
|
458.8
|
470.3
|
|
AG
|
33 (22.1)
|
25 (13.0)
|
0.54 (0.31–0.97)
|
- The lower the AIC and BIC values, the more accurate the model
- HFS hand-food syndrome, OR odds ratio, CI confidence interval, AIC Akaike’s information criterion, BIC Bayes information criterion, NA not applicable
