Table 3 Frequencies of 22 SNPs of 3 genes in metastatic breast cancer patients with and without capecitabine-induced HFS
Gene | SNPÂ | Genotype | Patients with HFS [cases (%)] | Patients without HFS [cases (%)] | P value |
|---|---|---|---|---|---|
Total | Â | Â | 193 | 149 | Â |
TYMS | rs2790 | AA | 78 (40.4) | 48 (32.2)Â | 0.316 |
| Â | GA | 87 (45.1) | 74 (49.7) | Â | |
| Â | GG | 26 (13.5) | 24 (16.1) | Â | |
| Â | NA | 2 (1.0) | 3 (2.0) | Â | |
rs15872 | TT | 73 (37.8) | 68 (45.6) | 0.265 | |
| Â | TC | 96 (49.7) | 61 (40.9) | Â | |
| Â | CC | 22 (11.4) | 17 (11.4) | Â | |
| Â | NA | 2 (1.0) | 3 (2.0) | Â | |
rs699517 | TT | 73 (37.8) | 70 (47.0) | 0.195 | |
| Â | TC | 97 (50.3) | 61 (40.9) | Â | |
| Â | CC | 20 (10.4) | 15 (10.1) | Â | |
| Â | NA | 3 (1.6) | 3 (2.0) | Â | |
rs1004474 | AA | 61 (31.6) | 45 (30.2) | 0.366 | |
| Â | GA | 97 (50.3) | 69 (46.3) | Â | |
| Â | GG | 32 (16.6) | 34 (22.8) | Â | |
| Â | NA | 3 (1.6) | 1 (0.7) | Â | |
rs2606241 | GG | 44 (22.8) | 34 (22.8) | 0.022 | |
| Â | GT | 113 (58.5) | 69 (46.3) | Â | |
| Â | TT | 33 (17.1) | 44 (29.5) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â | |
rs2853741 | TT | 38 (19.7) | 48 (32.2) | 0.019 | |
| Â | TC | 113 (58.5) | 68 (45.6) | Â | |
| Â | CC | 39 (20.2) | 31 (20.8) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â | |
rs3786362 | TT | 135 (69.9) | 86 (57.7) | 0.055 | |
| Â | CT | 48 (24.9) | 53 (35.6) | Â | |
| Â | CC | 7 (3.6) | 8 (5.4) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â | |
rs9947507 | TT | 193 (100.0) | 149 (100.0) | NA | |
rs9967368 | CC | 55 (28.5) | 52 (34.9) | 0.231 | |
| Â | CG | 97 (50.3) | 61 (40.9) | Â | |
| Â | GG | 38 (19.7) | 33 (22.1) | Â | |
| Â | NA | 3 (1.6) | 3 (2.0) | Â | |
MTHFR | rs1801131 | AA | 143 (74.1) | 101 (67.8) | 0.291 |
| Â | CA | 47 (24.4) | 45 (30.2) | Â | |
| Â | CC | 1 (0.5) | 1 (0.7) | Â | |
| Â | NA | 2 (1.0) | 2 (1.3) | Â | |
rs1801133 | TT | 60 (31.1) | 52 (34.9) | 0.662 | |
| Â | TC | 99 (51.3) | 69 (46.3) | Â | |
| Â | CC | 31 (16.1) | 25 (16.8) | Â | |
| Â | NA | 3 (1.6) | 3 (2.0) | Â | |
rs2274976 | GG | 163 (84.5) | 131 (87.9) | 0.558 | |
| Â | GA | 26 (13.5) | 17 (11.4) | Â | |
| Â | AA | 1 (0.5) | 0 (0.0) | Â | |
| Â | NA | 3 (1.6) | 1 (0.7) | Â | |
rs3737964 | GG | 165 (85.5) | 113 (75.8) | 0.029 | |
| Â | AG | 25 (13.0) | 33 (22.1) | Â | |
| Â | NA | 3 (1.6) | 3 (2.0) | Â | |
rs3753582 | TT | 160 (82.9) | 131 (87.9) | 0.389 | |
| Â | GT | 29 (15.0) | 15 (10.1) | Â | |
| Â | GG | 1 (0.5) | 1 (0.7) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â | |
rs4846048 | AA | 165 (85.5) | 115 (77.2) | 0.030 | |
| Â | AG | 25 (13.0) | 33 (22.1) | Â | |
| Â | NA | 3 (1.6) | 1 (0.7) | Â | |
rs4846049 | GG | 138 (71.5) | 97 (65.1) | 0.338 | |
| Â | GT | 49 (25.4) | 49 (32.9) | Â | |
| Â | TT | 3 (1.6) | 2 (1.3) | Â | |
| Â | NA | 3 (1.6) | 1 (0.7) | Â | |
RRM1 | rs720106 | AA | 142 (73.6) | 98 (65.8) | 0.054 |
| Â | AG | 40 (20.7) | 46 (30.9) | Â | |
| Â | GG | 7 (3.6) | 2 (1.3) | Â | |
| Â | NA | 4 (2.1) | 3 (2.0) | Â | |
rs725519 | AA | 142 (73.6) | 98 (65.8) | 0.532 | |
| Â | AG | 40 (20.7) | 46 (30.9) | Â | |
| Â | GG | 7 (3.6) | 2 (1.3) | Â | |
| Â | NA | 4 (2.1) | 3 (2.0) | Â | |
rs1042858 | AA | 116 (60.1) | 78 (52.3) | 0.491 | |
| Â | CA | 64 (33.2) | 56 (37.6) | Â | |
| Â | CC | 10 (5.2) | 9 (6.0) | Â | |
| Â | NA | 3 (1.6) | 6 (4.0) | Â | |
rs1042927 | AA | 118 (61.1) | 81 (54.4) | 0.415 | |
| Â | CA | 61 (31.6) | 57 (38.3) | Â | |
| Â | CC | 11 (5.6) | 9 (6.0) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â | |
rs1980412 | CC | 61 (31.6) | 58 (38.9) | 0.359 | |
| Â | TC | 102 (52.8) | 69 (46.3) | Â | |
| Â | TT | 26 (13.5) | 19 (12.8) | Â | |
| Â | NA | 4 (2.1) | 3 (2.0) | Â | |
rs11030918 | TT | 103 (53.4) | 74 (49.7) | 0.378 | |
| Â | CT | 66 (34.2) | 61 (40.9) | Â | |
| Â | CC | 21 (10.9) | 12 (8.1) | Â | |
| Â | NA | 3 (1.6) | 2 (1.3) | Â |