|
Gene
|
SNP
|
Genotype
|
Patients with HFS [cases (%)]
|
Patients without HFS [cases (%)]
|
P value
|
|---|
|
Total
| | |
193
|
149
| |
|
TYMS
|
rs2790
|
AA
|
78 (40.4)
|
48 (32.2)
|
0.316
|
| |
GA
|
87 (45.1)
|
74 (49.7)
| |
| |
GG
|
26 (13.5)
|
24 (16.1)
| |
| |
NA
|
2 (1.0)
|
3 (2.0)
| |
|
rs15872
|
TT
|
73 (37.8)
|
68 (45.6)
|
0.265
|
| |
TC
|
96 (49.7)
|
61 (40.9)
| |
| |
CC
|
22 (11.4)
|
17 (11.4)
| |
| |
NA
|
2 (1.0)
|
3 (2.0)
| |
|
rs699517
|
TT
|
73 (37.8)
|
70 (47.0)
|
0.195
|
| |
TC
|
97 (50.3)
|
61 (40.9)
| |
| |
CC
|
20 (10.4)
|
15 (10.1)
| |
| |
NA
|
3 (1.6)
|
3 (2.0)
| |
|
rs1004474
|
AA
|
61 (31.6)
|
45 (30.2)
|
0.366
|
| |
GA
|
97 (50.3)
|
69 (46.3)
| |
| |
GG
|
32 (16.6)
|
34 (22.8)
| |
| |
NA
|
3 (1.6)
|
1 (0.7)
| |
|
rs2606241
|
GG
|
44 (22.8)
|
34 (22.8)
|
0.022
|
| |
GT
|
113 (58.5)
|
69 (46.3)
| |
| |
TT
|
33 (17.1)
|
44 (29.5)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
|
rs2853741
|
TT
|
38 (19.7)
|
48 (32.2)
|
0.019
|
| |
TC
|
113 (58.5)
|
68 (45.6)
| |
| |
CC
|
39 (20.2)
|
31 (20.8)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
|
rs3786362
|
TT
|
135 (69.9)
|
86 (57.7)
|
0.055
|
| |
CT
|
48 (24.9)
|
53 (35.6)
| |
| |
CC
|
7 (3.6)
|
8 (5.4)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
|
rs9947507
|
TT
|
193 (100.0)
|
149 (100.0)
|
NA
|
|
rs9967368
|
CC
|
55 (28.5)
|
52 (34.9)
|
0.231
|
| |
CG
|
97 (50.3)
|
61 (40.9)
| |
| |
GG
|
38 (19.7)
|
33 (22.1)
| |
| |
NA
|
3 (1.6)
|
3 (2.0)
| |
|
MTHFR
|
rs1801131
|
AA
|
143 (74.1)
|
101 (67.8)
|
0.291
|
| |
CA
|
47 (24.4)
|
45 (30.2)
| |
| |
CC
|
1 (0.5)
|
1 (0.7)
| |
| |
NA
|
2 (1.0)
|
2 (1.3)
| |
|
rs1801133
|
TT
|
60 (31.1)
|
52 (34.9)
|
0.662
|
| |
TC
|
99 (51.3)
|
69 (46.3)
| |
| |
CC
|
31 (16.1)
|
25 (16.8)
| |
| |
NA
|
3 (1.6)
|
3 (2.0)
| |
|
rs2274976
|
GG
|
163 (84.5)
|
131 (87.9)
|
0.558
|
| |
GA
|
26 (13.5)
|
17 (11.4)
| |
| |
AA
|
1 (0.5)
|
0 (0.0)
| |
| |
NA
|
3 (1.6)
|
1 (0.7)
| |
|
rs3737964
|
GG
|
165 (85.5)
|
113 (75.8)
|
0.029
|
| |
AG
|
25 (13.0)
|
33 (22.1)
| |
| |
NA
|
3 (1.6)
|
3 (2.0)
| |
|
rs3753582
|
TT
|
160 (82.9)
|
131 (87.9)
|
0.389
|
| |
GT
|
29 (15.0)
|
15 (10.1)
| |
| |
GG
|
1 (0.5)
|
1 (0.7)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
|
rs4846048
|
AA
|
165 (85.5)
|
115 (77.2)
|
0.030
|
| |
AG
|
25 (13.0)
|
33 (22.1)
| |
| |
NA
|
3 (1.6)
|
1 (0.7)
| |
|
rs4846049
|
GG
|
138 (71.5)
|
97 (65.1)
|
0.338
|
| |
GT
|
49 (25.4)
|
49 (32.9)
| |
| |
TT
|
3 (1.6)
|
2 (1.3)
| |
| |
NA
|
3 (1.6)
|
1 (0.7)
| |
|
RRM1
|
rs720106
|
AA
|
142 (73.6)
|
98 (65.8)
|
0.054
|
| |
AG
|
40 (20.7)
|
46 (30.9)
| |
| |
GG
|
7 (3.6)
|
2 (1.3)
| |
| |
NA
|
4 (2.1)
|
3 (2.0)
| |
|
rs725519
|
AA
|
142 (73.6)
|
98 (65.8)
|
0.532
|
| |
AG
|
40 (20.7)
|
46 (30.9)
| |
| |
GG
|
7 (3.6)
|
2 (1.3)
| |
| |
NA
|
4 (2.1)
|
3 (2.0)
| |
|
rs1042858
|
AA
|
116 (60.1)
|
78 (52.3)
|
0.491
|
| |
CA
|
64 (33.2)
|
56 (37.6)
| |
| |
CC
|
10 (5.2)
|
9 (6.0)
| |
| |
NA
|
3 (1.6)
|
6 (4.0)
| |
|
rs1042927
|
AA
|
118 (61.1)
|
81 (54.4)
|
0.415
|
| |
CA
|
61 (31.6)
|
57 (38.3)
| |
| |
CC
|
11 (5.6)
|
9 (6.0)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
|
rs1980412
|
CC
|
61 (31.6)
|
58 (38.9)
|
0.359
|
| |
TC
|
102 (52.8)
|
69 (46.3)
| |
| |
TT
|
26 (13.5)
|
19 (12.8)
| |
| |
NA
|
4 (2.1)
|
3 (2.0)
| |
|
rs11030918
|
TT
|
103 (53.4)
|
74 (49.7)
|
0.378
|
| |
CT
|
66 (34.2)
|
61 (40.9)
| |
| |
CC
|
21 (10.9)
|
12 (8.1)
| |
| |
NA
|
3 (1.6)
|
2 (1.3)
| |
- P value < 0.05 was considered statistically significant (in italics)
- SNP, single nucleotide polymorphism; HFS, hand-foot syndrome; TYMS, thymidylate synthase; MTHFR, methylene tetrahydrofolate reductase; RRM1, ribonucleotide reductase M1; NA, not applicable
