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Table 5 Multivariate analysis for PFS and OS of 216 patients with multiple myeloma

From: Poor outcomes of immunoglobulin D multiple myeloma patients in the era of novel agents: a single-center experience

Variable

PFS

OS

HR

95% CI

P value

HR

95% CI

P value

LDH > 250 U/L

1.494

1.020–2.189

0.039

2.791

1.692–4.604

< 0.001

ISS stage III

1.298

1.032–1.633

0.026

1.533

1.096–2.145

0.013

IgD subtype

2.221

1.221–4.040

0.009

3.506

1.687–7.285

0.001

1q21 amplification

1.949

1.179–3.224

0.009

IGH rearrangement

1.615

1.260–2.071

< 0.001

1.485

1.165–1.895

0.001

Extramedullary infiltration

2.084

1.421–3.055

< 0.001

3.692

2.199–6.200

< 0.001

  1. PFS progression-free survival, OS overall survival, HR hazard ratio, CI confidence interval, LDH lactate dehydrogenase, ISS international staging system, IgD immunoglobulin D, IGH immunoglobulin heavy chain gene