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Table 5 Multivariate analysis for PFS and OS of 216 patients with multiple myeloma

From: Poor outcomes of immunoglobulin D multiple myeloma patients in the era of novel agents: a single-center experience

Variable PFS OS
HR 95% CI P value HR 95% CI P value
LDH > 250 U/L 1.494 1.020–2.189 0.039 2.791 1.692–4.604 < 0.001
ISS stage III 1.298 1.032–1.633 0.026 1.533 1.096–2.145 0.013
IgD subtype 2.221 1.221–4.040 0.009 3.506 1.687–7.285 0.001
1q21 amplification 1.949 1.179–3.224 0.009
IGH rearrangement 1.615 1.260–2.071 < 0.001 1.485 1.165–1.895 0.001
Extramedullary infiltration 2.084 1.421–3.055 < 0.001 3.692 2.199–6.200 < 0.001
  1. PFS progression-free survival, OS overall survival, HR hazard ratio, CI confidence interval, LDH lactate dehydrogenase, ISS international staging system, IgD immunoglobulin D, IGH immunoglobulin heavy chain gene