Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China

Table 3 Accuracy of clinical diagnostic criteria, IHC of MMR proteins, and MSI test in screening Lynch syndrome-associated endometrial carcinoma

Screening method	NGS (cases)		Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Screening method	LS-EC	Non-LS-EC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Total	6	105
Clinical criteria			33.3	88.6	14.3	95.9
Met	2	12
Unmet	4	93
IHC			66.7	75.0	33.3	100
MMR-deficient	4	24
MMR-intact	2	72
MSI			100.0	89.9	33.3	100.0
Positive	4	8
Negative	0	71
IHC plus MSI			100.0	72.4	20.0	100.0
MMR-deficient or MSI-positive	6	24
MMR-intact and MSI-negative	0	63

Due to insufficient tumor tissues for examination, IHC was performed for only 102 patients, and MSI test was performed for 83 patients
IHC: immunohistochemistry; MMR: mismatch repair; MSI: microsatellite instability; NGS: next-generation sequencing; LS-EC: Lynch syndrome-associated endometrial carcinoma; NPV: negative predictive value; PPV: positive predictive value

ISSN: 2523-3548