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Table 3 Accuracy of clinical diagnostic criteria, IHC of MMR proteins, and MSI test in screening Lynch syndrome-associated endometrial carcinoma

From: Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China

Screening method NGS (cases) Sensitivity (%) Specificity (%) PPV (%) NPV (%)
LS-EC Non-LS-EC
Total 6 105     
Clinical criteria    33.3 88.6 14.3 95.9
 Met 2 12     
 Unmet 4 93     
IHC    66.7 75.0 33.3 100
 MMR-deficient 4 24     
 MMR-intact 2 72     
MSI    100.0 89.9 33.3 100.0
 Positive 4 8     
 Negative 0 71     
IHC plus MSI    100.0 72.4 20.0 100.0
 MMR-deficient or MSI-positive 6 24     
 MMR-intact and MSI-negative 0 63     
  1. Due to insufficient tumor tissues for examination, IHC was performed for only 102 patients, and MSI test was performed for 83 patients
  2. IHC: immunohistochemistry; MMR: mismatch repair; MSI: microsatellite instability; NGS: next-generation sequencing; LS-EC: Lynch syndrome-associated endometrial carcinoma; NPV: negative predictive value; PPV: positive predictive value