Fig. 2

An example of immunohistochemistry (IHC) of mismatch repair (MMR) proteins from Case 4 in Table 2. This patient was 53 years at diagnosis and was confirmed to have grade 1 stage IA uterine endometrioid carcinoma. Two years before the diagnosis of endometrial cancer, she was diagnosed with early-stage colon cancer. Her father and daughter had a history of colon cancer and small intestine cancer, respectively. a Deficient expression of MutL homolog 1 (MLH1) protein in tumor tissues. The cytoplasm of almost all cancer cells had no staining in brown. b Normal expression of MutS homolog 2 (MSH2) protein in tumor tissues. The cytoplasm of cancer cells had homogeneous brown staining. c Normal expression of MutS homolog 6 (MSH6) protein in tumor tissues. The cytoplasm of cancer cells had homogeneous brown staining. d Deficient expression of PMS1 homolog 2 (PMS2) protein in tumor tissues. The cytoplasm of all cancer cells had no staining in brown