|
General disorder
|
|
Fatigue
|
150 (51.0)
|
1 (0.3)
|
38 (26.6)
|
0
|
|
Anorexia
|
133 (45.2)
|
3 (1.0)
|
43 (30.1)
|
3 (2.1)
|
|
Weight loss
|
66 (22.4)
|
0
|
12 (8.4)
|
0
|
|
Pain
|
42 (14.3)
|
2 (0.7)
|
15 (10.5)
|
2 (1.4)
|
|
Gastrointestinal disorder
|
|
Diarrhea
|
103 (35.0)
|
3 (1.0)
|
21 (14.7)
|
0
|
|
Oropharyngeal pain
|
83 (28.2)
|
1 (0.3)
|
10 (7.0)
|
0
|
|
Oral mucositis
|
68 (23.1)
|
3 (1.0)
|
4 (2.8)
|
0
|
|
Vomiting
|
63 (21.4)
|
1 (0.3)
|
19 (13.3)
|
0
|
|
Abdominal pain
|
53 (18.0)
|
1 (0.3)
|
13 (9.1)
|
0
|
|
Nausea
|
52 (17.7)
|
0
|
19 (13.3)
|
0
|
|
Gum pain
|
40 (13.6)
|
0
|
2 (1.4)
|
0
|
|
Respiratory, thoracic, or mediastinal disorder
|
|
Cough
|
110 (37.4)
|
2 (0.7)
|
33 (23.1)
|
1 (0.7)
|
|
Dyspnea
|
90 (30.6)
|
6 (2.0)
|
32 (22.4)
|
7 (4.9)
|
|
Cacophonia
|
66 (22.4)
|
2 (0.7)
|
7 (4.9)
|
1 (0.7)
|
|
Hemoptysis
|
58 (19.7)
|
9 (3.1)
|
11 (7.7)
|
2 (1.4)
|
|
Sputum
|
49 (16.7)
|
2 (0.7)
|
16 (11.2)
|
1 (0.7)
|
|
Upper respiratory infection
|
33 (11.2)
|
0
|
3 (2.1)
|
0
|
|
Pneumonia
|
28 (9.5)
|
12 (4.1)
|
9 (6.3)
|
3 (2.1)
|
|
Respiratory failure
|
10 (3.4)
|
10 (3.4)
|
3 (2.1)
|
3 (2.1)
|
|
Cardiovascular disorder
|
|
Hypertension
|
198 (67.3)
|
40 (13.6)
|
23 (16.1)
|
0
|
|
Sinus tachycardia
|
105 (35.7)
|
0
|
47 (32.9)
|
0
|
|
QTc prolongations
|
77 (26.2)
|
7 (2.4)
|
27 (18.9)
|
2 (1.4)
|
|
Skin and subcutaneous tissue disorder
|
|
Hand–foot syndrome
|
128 (43.5)
|
11 (3.7)
|
13 (9.1)
|
0
|
|
Rash
|
35 (11.9)
|
0
|
11 (7.7)
|
1 (0.7)
|
|
Musculoskeletal and connective tissue disorder
|
|
Chest arthralgia
|
54 (18.4)
|
1 (0.3)
|
17 (11.9)
|
3 (2.1)
|
|
Lumbar and rib pain
|
42 (14.3)
|
0
|
11 (7.7)
|
0
|
|
Limbs pain
|
39 (13.3)
|
0
|
16 (11.2)
|
1 (0.7)
|
|
Kidney and urinary system disorder
|
|
Proteinuria
|
85 (28.9)
|
7 (2.4)
|
19 (13.3)
|
1 (0.7)
|
|
Hematuria
|
41 (13.9)
|
0
|
8 (5.6)
|
0
|
|
Urinary tract infection
|
33 (11.2)
|
0
|
6 (4.2)
|
0
|
|
Endocrine system disorder
|
|
Hypothyroidism
|
57 (19.4)
|
1 (0.3)
|
5 (3.5)
|
0
|
|
Nervous system disorder
|
|
Dizziness
|
33 (11.2)
|
0
|
13 (9.1)
|
0
|
|
Headache
|
32 (10.9)
|
0
|
5 (3.5)
|
0
|
|
Laboratory test abnormality
|
|
Elevated TSH
|
137 (46.6)
|
1 (0.3)
|
9 (6.3)
|
0
|
|
Hyper triglycerides
|
126 (42.9)
|
9 (3.1)
|
34 (23.8)
|
0
|
|
Hypercholesterolemia
|
119 (40.5)
|
0
|
20 (14.0)
|
0
|
|
Hyper γ-glutamyl transferase
|
87 (29.6)
|
13 (4.4)
|
26 (18.2)
|
9 (6.3)
|
|
Hyperbilirubinemia
|
76 (25.9)
|
5 (1.7)
|
21 (14.7)
|
2 (1.4)
|
|
Hyponatremia
|
66 (22.4)
|
24 (8.2)
|
12 (8.4)
|
5 (3.5)
|
|
Hyper LDL
|
60 (20.4)
|
2 (0.7)
|
11 (7.7)
|
0
|
|
Lymphocytopenia
|
55 (18.7)
|
14 (4.8)
|
27 (18.9)
|
8 (5.6)
|
|
Hypoalbuminemia
|
53 (18.0)
|
1 (0.3)
|
18 (12.6)
|
1 (0.7)
|
|
Elevated alkaline phosphatase
|
48 (16.3)
|
7 (2.4)
|
18 (12.6)
|
4 (2.8)
|
|
Elevated alanine transaminase
|
46 (15.6)
|
2 (0.7)
|
13 (9.1)
|
0
|
|
Elevated aspartate transaminase
|
44 (15.0)
|
3 (1.0)
|
15 (10.5)
|
0
|
|
Hypophosphatemia
|
31 (10.5)
|
4 (1.4)
|
10 (7.0)
|
2 (1.4)
|
|
Hypokalemia
|
31 (10.5)
|
2 (0.7)
|
7 (4.9)
|
0
|
|
Thrombocytopenia
|
30 (10.2)
|
3 (1.0)
|
6 (4.2)
|
0
|
|
Elevated lipase
|
17 (5.8)
|
7 (2.4)
|
2 (1.4)
|
1 (0.7)
|
