Table 2 Univariate analysis of overall survival and disease-free survival according to clinical and histopathological characteristics
From: Modelling the probability of erroneous negative lymph node staging in patients with colon cancer
Characteristic | Overall survival | Disease-free survival | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age | 1.05 (1.03–1.07) | < 0.001 | 1.00 (0.99–1.02) | 0.456 |
Gender (female vs. male) | 1.14 (0.87–1.49) | 0.672 | 1.00 (0.69–1.46) | 0.687 |
Location (left colon vs. right colon) | 1.07 (0.80–1.40) | 0.493 | 1.36 (0.91–2.04) | 0.116 |
Histological classification (adenocarcinoma vs. mucinous variant vs. signet-ring cell) | 1.12 (0.82–1.54) | 0.227 | 1.25 (0.82–1.92) | 0.180 |
Tumour differentiation grade (well vs. moderate vs. poor) | 1.07 (0.87–1.33) | 0.245 | 1.17 (0.87–1.59) | 0.677 |
Tumour size | 1.00 (0.99–1.01) | 0.660 | 1.00 (0.99–1.01) | 0.399 |
Lymphadenectomy | ||||
Number of analysed LNs | 0.97 (0.95–0.99) | 0.073 | 0.99 (0.97–1.02) | 0.990 |
< 12 analysed LNs (yes vs. no) | 0.74 (0.56–0.98) | 0.025 | 0.90 (0.61–1.31) | 0.874 |
pT (6th edition, pT1 vs. pT2 vs. pT3 vs. pT4) | 1.79 (1.44–2.22) | < 0.001 | 1.87 (1.38–2.53) | 0.006 |
pN (7th edition, pN0 vs. pN1a vs. PN1b vs. pN2a vs. pN2b) | 1.22 (1.10–1.35) | < 0.001 | 1.89 (1.49–2.41) | < 0.001 |
Condensed TNM (7th edition, stage I vs. stage II) | 1.55 (1.27–1.90) | < 0.001 | 1.89 (1.41–2.52) | 0.001 |
FEP | 1.51 (1.09–2.10) | 0.019 | 1.59 (0.98–2.59) | 0.185 |
Chemotherapy (yes vs. no) | 0.62 (0.45–0.84) | 0.014 | 1.93 (1.33–2.81) | < 0.001 |
Locoregional recurrence (yes vs. no) | 2.28 (1.54–3.38) | < 0.001 | 12.28 (8.13–15.54) | < 0.001 |
Metastasis (yes vs. no) | 3.51 (2.66–4.65) | < 0.001 | 67.95 (39.68–116.33) | < 0.001 |