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Table 2 Univariate analysis of overall survival and disease-free survival according to clinical and histopathological characteristics

From: Modelling the probability of erroneous negative lymph node staging in patients with colon cancer

Characteristic Overall survival Disease-free survival
HR (95% CI) P value HR (95% CI) P value
Age 1.05 (1.03–1.07) < 0.001 1.00 (0.99–1.02) 0.456
Gender (female vs. male) 1.14 (0.87–1.49) 0.672 1.00 (0.69–1.46) 0.687
Location (left colon vs. right colon) 1.07 (0.80–1.40) 0.493 1.36 (0.91–2.04) 0.116
Histological classification (adenocarcinoma vs. mucinous variant vs. signet-ring cell) 1.12 (0.82–1.54) 0.227 1.25 (0.82–1.92) 0.180
Tumour differentiation grade (well vs. moderate vs. poor) 1.07 (0.87–1.33) 0.245 1.17 (0.87–1.59) 0.677
Tumour size 1.00 (0.99–1.01) 0.660 1.00 (0.99–1.01) 0.399
Lymphadenectomy
 Number of analysed LNs 0.97 (0.95–0.99) 0.073 0.99 (0.97–1.02) 0.990
 < 12 analysed LNs (yes vs. no) 0.74 (0.56–0.98) 0.025 0.90 (0.61–1.31) 0.874
pT (6th edition, pT1 vs. pT2 vs. pT3 vs. pT4) 1.79 (1.44–2.22) < 0.001 1.87 (1.38–2.53) 0.006
pN (7th edition, pN0 vs. pN1a vs. PN1b vs. pN2a vs. pN2b) 1.22 (1.10–1.35) < 0.001 1.89 (1.49–2.41) < 0.001
Condensed TNM (7th edition, stage I vs. stage II) 1.55 (1.27–1.90) < 0.001 1.89 (1.41–2.52) 0.001
FEP 1.51 (1.09–2.10) 0.019 1.59 (0.98–2.59) 0.185
Chemotherapy (yes vs. no) 0.62 (0.45–0.84) 0.014 1.93 (1.33–2.81) < 0.001
Locoregional recurrence (yes vs. no) 2.28 (1.54–3.38) < 0.001 12.28 (8.13–15.54) < 0.001
Metastasis (yes vs. no) 3.51 (2.66–4.65) < 0.001 67.95 (39.68–116.33) < 0.001
  1. HR hazard ratio, CI confidence intervals, ADC adenocarcinoma, LN lymph node, TNM tumor-node-metastasis, FEP final error probability