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Fig. 3 | Cancer Communications

Fig. 3

From: PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer

Fig. 3

PD-L1 and PD-L2 expression correlated genes converge differently with immune-related gene signatures. a Diagram illustrating the number of common genes for various gene signatures (shown to the left) and expression correlated genes for PD-L1, PD-L2, and both, from dataset Lung_NSC, LUSC, and LUAD (shown at the top). The color indicates the percentage of the signature genes being PD-L1 and PD-L2 expression correlated. The gene signature IFN signaling is composed of IFNG, IFNGR1, IFNGR2, IFNAR1, IFNAR2, JAK1, JAK2, TYK2, STAT1, STAT2, STAT3, IRF1, and IRF9; the gene signature IFN signaling core is composed of STAT1, JAK1, JAK2, IRF1, and IRF9; the gene signatures IFN-γ, expanded immune, and T cell inflamed were from Ayers et al. [40]; immune cell type gene signatures are from Garcia-Diaz et al. [21]; PD-L1 and PD-L2 expression correlation signatures were from the present study; and the gene signature cognate receptors is composed of PD-1, CD80, and RGMB. bd Venn diagrams illustrating the number of genes expression correlated with both PD-L1 and PD-L2 b, PD-L1 c, and PD-L2 d in Lung_NSC, LUAD, and LUSC. For all panels, the criteria for significant expression correlation were Pearson correlation coefficient r ≥ 0.3 or ≤ − 0.3, Spearman correlation coefficient r ≥ 0.4 or ≤ − 0.4, and P values < 0.05

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