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Table 1 Association of patient clinicopathological characteristics with overall survival

From: A homogenized approach to classify advanced gastric cancer patients with limited and adequate number of pathologically examined lymph nodes

Characteristic Total [cases (%)] 5-year OS (%) HR (95% CI) P-value
Gender 0.956
 Male 1603 (69.6) 57.2 Ref.  
 Female 701 (30.4) 56.8 1.004 (0.700–1.158)  
Age (years) < 0.001
 ≤ 60 1226 (53.2) 61.1 Ref.  
 > 60 1078 (46.8) 52.5 1.316 (1.154–1.501)  
Tumor location < 0.001
 Lower 1/3 839 (36.4) 67.9 Ref.  
 Middle 1/3 393 (17.1) 56.9 1.450 (1.184–1.776)  
 Upper 1/3 967 (42.0) 51.0 1.720 (1.471–2.010)  
 > 1/3 of stomach 105 (4.6) 25.4 3.581 (2.723–4.708)  
Tumor size (cm) < 0.001
 ≤ 4.5 1180 (51.2) 64.8 Ref.  
 > 4.5 1124 (48.8) 49.0 1.600 (1.401–1.827)  
Lauren type < 0.001
 Intestinal 804 (34.9) 62.9 Ref.  
 Diffuse 1500 (65.1) 54.0 1.364 (1.182–1.575)  
Type of gastrectomy < 0.001
 Partial 1844 (80.0) 60.3 Ref.  
 Total 460 (20.0) 41.4 1.721 (1.471–2.014)  
Examined lymph nodes 0.003
 < 16 794 (34.5) 53.3 Ref.  
 ≥ 16 1510 (65.5) 59.3 0.817 (0.715–0.934)  
8th AJCC pT classification < 0.001
 T2 297 (12.9) 85.5 Ref.  
 T3 492 (21.4) 65.5 2.203 (1.578–3.074)  
 T4a 1296 (56.3) 51.5 3.588 (2.666–4.831)  
 T4b 219 (9.5) 35.3 5.717 (4.087–7.996)  
8th AJCC pN classification < 0.001
 N0 653 (28.3) 82.7 Ref.  
 N1 434 (18.8) 65.2 2.192 (1.705–2.818)  
 N2 491 (21.3) 49.4 3.651 (2.906–4.589)  
 N3a 489 (21.2) 37.8 5.078 (4.050–6.367)  
 N3b 237 (10.3) 24.8 7.684 (6.001–9.839)  
LNR classification
 LNR 1 666 (28.9) 82.5 Ref. < 0.001
 LNR 2 285 (12.4) 72.5 1.682 (1.246–2.270)  
 LNR 3 499 (21.7) 57.3 2.830 (2.237–3.580)  
 LNR 4 360 (15.6) 42.1 4.371 (3.458–5.526)  
 LNR 5 494 (21.4) 25.4 7.465 (6.004–9.281)  
N′ classification < 0.001
 N′0 382 (16.6) 87.5 Ref.  
 N′1 498 (21.6) 75.1 2.314 (1.612–3.321)  
 N′2 489 (21.2) 59.1 4.348 (3.080–6.137)  
 N′3a 591 (25.7) 40.4 7.170 (5.138–10.006)  
 N′3b 344 (14.9) 23.1 12.713 (9.046–17.866)  
8th AJCC pTNM classification < 0.001
 IB 162 (7.0) 94.8 Ref.  
 IIA 202 (8.8) 85.3 2.353 (1.175–4.710)  
 IIB 476 (20.7) 75.5 3.830 (2.060–7.123)  
 IIIA 674 (29.3) 54.7 8.168 (4.473–14.915)  
 IIIB 501 (21.7) 38.8 12.800 (6.999–23.412)  
 IIIC 289 (12.5) 23.2 20.845 (11.338–38.322)  
TN′M classification < 0.001
 IB′ 105 (4.6) 96.9 Ref.  
 IIA′ 178 (7.7) 90.7 2.845 (0.972–8.324)  
 IIB′ 362 (15.7) 77.8 5.103 (1.860–14.000)  
 IIIA′ 685 (29.7) 64.6 9.839 (3.662–26.434)  
 IIIB′ 569 (24.7) 42.2 18.918 (7.052–50.750)  
 IIIC′ 405 (17.6) 22.4 34.795 (12.961–93.409)  
  1. OS overall survival, HR hazard ratio, CI confidence interval, AJCC American Joint Committee on Cancer, pN pathologically examined nodal classification, N′ pathologically examined modified nodal classification, pTNM pathological tumor-node-metastasis classification, TNM pathological tumor-modified node-metastasis classification, LNR lymph-node-ratio, Ref. reference