Fig. 2

Kaplan–Meier analyses confirming that gene signatures were associated with patients’ overall survival. a Validation of signature 1 (green panels) across multiple cancer types. Kaplan–Meier plots of overall survival in cancer patients stratified based on signature 1 mean expression scores. Patients were median-dichotomized into high- and low-score groups. Signature 1 is a marker of good prognosis, and hence patients with high signature 1 scores had high survival rates. b Validation of signature 2 (red panels) across multiple cancer types. Kaplan–Meier plots of overall survival in cancer patients stratified based on signature 2 mean expression scores. Patients were median-dichotomized into high- and low-score groups. Signature 2 is a marker of adverse prognosis, and hence patients with high signature 2 scores had low survival rates. P values were calculated from the log-rank test. Pancreas #1 = PAAD cohort; Pancreas #2 = PACA-AU cohort; Pancreas #3 = PACA-CA cohort; Liver #1 = LIHC cohort; Liver #2 = LIRI-JP cohort; and Liver #3 = GSE14520 cohort (Additional file 1)