Fig. 1

Schematic diagram of the study design and development of signatures derived from 61 2-oxoglutarate-dependent oxygenase genes. a Three pancreatic adenocarcinoma cohorts were used to define both signatures 1 and 2. Genes found to be prognostic in univariate Cox regression analysis in 2 out of 3 pancreatic adenocarcinoma cohorts were included in signatures 1 and 2. Signature 1 is a marker of good prognosis and consists of 5 genes (KDM8, KDM6B, P4HTM, ALKBH4, and ALKBH7). Signature 2 is a marker of adverse prognosis and consists of 5 genes (KDM3A, P4HA1, ASPH, PLOD1, and PLOD2). Prognosis of both signatures was further confirmed in 10 cancer types using Kaplan–Meier, Cox regression, and receiver operating characteristic analyses. b Forest plots of prognostic genes found to be significant by univariate Cox regression analysis in pancreatic adenocarcinoma cohorts abbreviated as PAAD, PACA-AU, and PACA-CA. Genes were separated into two groups, good and bad prognostic genes. Hazard ratios were denoted as red circles, and turquoise bars represent 95% confidence interval. Significant Wald test P values are indicated in blue. Y-axes represent gene symbols followed by cohort abbreviations. Signature 1 genes are marked in green. Signature 2 genes are marked in red. Full description of cancers is listed in Additional file 1. 2OG, 2-oxoglutarate; TCGA, The Cancer Genome Atlas; ICGC, International Cancer Genome Consortium