Table 3 The rate of treatment-related adverse events of the study cohort
Adverse event | Frequency [cases (%)] | |||
|---|---|---|---|---|
Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
Hematologic | ||||
Neutropenia | 20 (30.8) | 15 (23.1) | 4 (6.2) | 4 (6.2) |
Thrombocytopenia | 9 (13.8) | 2 (3.1) | 0 | 0 |
Anemia | 24 (36.9) | 3 (4.6) | 0 | 1 (1.5) |
Nonhematologic | ||||
Loss of appetite | 34 (52.3) | 18 (27.7) | 0 | 0 |
Nausea | 26 (40.0) | 18 (27.7) | 0 | 0 |
Vomiting | 14 (21.5) | 19 (29.2) | 1 (1.5) | 0 |
Mucosal inflammation | 14 (21.5) | 1 (1.5) | 0 | 0 |
Diarrhea | 20 (30.8) | 4 (6.2) | 4 (6.2) | 0 |
Alopecia | 52 (80.0) | 13 (20.0) | – | – |
Fatigue | 25 (38.5) | 10 (15.4) | 0 | 0 |
Sensory neuropathy | 18 (27.7) | 3 (4.6) | 0 | 0 |
Weight loss | 7 (10.8) | 0 | 0 | 0 |
Constipation | 7 (10.8) | 1 (1.5) | 0 | 0 |
Alanine aminotransferase elevation | 22 (33.8) | 7 (10.8) | 1 (1.5) | 0 |
Aspartate aminotransferase elevation | 12 (18.5) | 4 (6.2) | 0 | 0 |
Bilirubin elevation | 4 (6.2) | 0 | 0 | 0 |
Allergic reaction | 1 (1.5) | 0 | 0 | 0 |
Rash | 1 (1.5) | 0 | 0 | 0 |
Hand-foot syndrome | 1 (1.5) | 0 | 0 | 0 |
Singultus | 1 (1.5) | 0 | 0 | 0 |