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Fig. 2 | Cancer Communications

Fig. 2

From: Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

Fig. 2

Copy number alterations (CNAs) in plasma cfDNA of chemorefractory and chemosensitive SCLC patients. a The heat-map shows CNA profiles of Src homology 2 domain containing protein 5 (SH2D5), carbonic anhydrase 12 (CA12), Lamin A/C (LMNA), Patched 1 (PTCH1), and DNA Ligase 4 (LIG4) identified in plasma cfDNA of each patient. CNA gains are shown in red, and CNA losses are shown in blue. b The heat-map shows hierarchical clustering of the 5 genes which failed to separate chemosensitive (blue) and chemorefractory (green) SCLC patients. c PCA of somatic mutation number profiles of individual cfDNA from chemosensitive and chemorefractory patients. The percentage variance for each of the principal components is given in parentheses, with separation of chemosensitive and chemorefractory patients seen at the somatic mutation level

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