Skip to main content


Fig. 1 | Cancer Communications

Fig. 1

From: Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer

Fig. 1

Somatic mutation statuses of genes in plasma cell-free DNA (cfDNA) of chemorefractory and chemosensitive small cell lung cancer (SCLC) patients. a The heat-map shows somatic mutation number profiles of adenomatous polyposis coli (APC), tumor protein 53 (TP53), ataxiatelangiectasia mutated (ATM), and folliculin (FLCN) identified in plasma cfDNA from each patient. Genes with high mutation numbers are shown in red, and those with low mutation numbers are shown in blue. b The heat-map shows hierarchical clustering of the 4 genes which briefly separate chemosensitive (blue) and chemorefractory (green) SCLC patients. c Differences in somatic mutation numbers of APC, ATM, TP53, and FLCN between the chemorefractory and chemosensitive groups. The data were statistically evaluated with two-tailed t-test. The bars indicate standard deviation. *P < 0.05. d Kaplan–Meier plots illustrate progression-free survival estimates for SCLC patients with and without mutations of APC, ATM, TP53, and FLCN. e Principal component analysis (PCA) of somatic mutation number profiles of individual cfDNA from chemosensitive and chemorefractory patients. The percentage variance for each of the principal components is given in parentheses, with separation of chemosensitive and chemorefractory patients seen at the somatic mutation level

Back to article page