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Table 2 Ingenuity analysis of top ranked pathways of differentially involved metabolites between BaF3/ITD and BaF3/ITD-R cells

From: Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Pathway

Ratioa

P value

Purine ribonucleoside degradation to ribose-1 phosphate

6/12 (50%)

1.93E−08

Purine nucleotides degradation

6/17 (35.3%)

2.43E−07

Adenine and adenosine salvage

4/10 (40.0%)

1.85E−05

Adenosine nucleotides degradation

4/11 (36.4%)

2.87E−05

Guanosine nucleotides degradation

3/10 (30.0%)

6.35E−04

  1. aRatio: The number of molecules from the focus gene set that map to the pathway to the total number of molecules that map to the canonical pathway
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Cancer Communications

ISSN: 2523-3548

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