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TableĀ 1 Differentially expressed metabolites between BaF3/ITD and BaF3/ITD-R cells

From: Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Metabolites name Retention time Compound MW Compound formula Ratio ITD-R/ITD P value
Guanine 4.38 151.04938 C5H5N5O 9.18 0.0219
Creatine 10.42 131.06949 C4H9N3O2 5.13 0.0094
Creatinine 6.78 113.05898 C4H7N3O 3.60 0.0077
l-2-Aminoadipic acid 8.09 161.06883 C6H11NO4 3.19 0.0111
Glyceraldehyde 2.17 90.03173 C3H6O3 2.81 0.0308
5-Hydroxytryptophol 11.13 177.0789 C10H11NO2 2.32 0.0133
l-Glutamate 10.55 147.05315 C5H9NO4 2.29 0.0022
d-Alanine 9.98 89.04769 C3H7NO2 1.91 0.0063
N1-Acetylspermidine 14.57 187.16841 C9H21N3O 1.82 0.0038
Glyceryl phosphate 11.22 172.01370 C3H9O6P 1.73 0.0053
4-Hydroxy-4(3-pyridyl)-butanoic acid 3.39 181.07387 C9H11NO3 1.62 0.0004
4-(3-Pyridyl)-butanoic acid 7.57 165.07907 C9H11NO2 1.61 0.0099
Guanosine 4.49 283.09139 C10H13N5O5 1.54 0.0012
l-1-Pyrroline-3-hydroxy-5-carboxylate 8.99 129.04265 C5H7NO3 1.53 0.0027
d-Lysine 13.39 146.10550 C6H14N2O2 1.53 0.0125
l-Isoleucine 8.26 131.09465 C6H13NO2 1.48 0.0066
l-Pipecolic acid 13.39 129.07909 C6H11NO2 1.44 0.0100
l-Histidine 8.99 155.06957 C6H9N3O2 1.43 0.0014
l-Glutamine 10.04 146.06911 C5H10N2O3 1.33 0.0041
Citrulline 10.73 175.09569 C6H13N3O3 1.32 0.0017
l-Ornithine 12.73 132.08993 C5H12N2O2 1.32 0.0019
l-Methionine 8.17 149.05103 C5H11NO2S 1.30 0.0076
l-Tryptophan 7.36 204.08989 C11H12N2O2 1.24 0.0208
Serotonin 6.85 176.09497 C10H12N2O 0.02 0.0062
l-Fucose1-phosphate 10.25 244.03486 C6H13O8P 0.09 0.0035
S-Formylglutathione 14.48 335.08000 C11H17N3O7S 0.15 0.0029
Uric acid 3.15 168.02832 C5H4N4O3 0.18 0.0037
Hypoxanthine 3.15 136.03855 C5H4N4O 0.20 0.0018
Inosine 3.48 268.08068 C10H12N4O5 0.22 0.0104
N-Acetyl-l-lysine 11.34 188.11614 C8H16N2O3 0.36 0.0008
l-Asparagine 9.96 132.05348 C4H8N2O3 0.45 0.0017
Trans-4-Hydroxy-l-proline 9.79 131.05832 C5H9NO3 0.42 0.0101
Adenosine 4.42 267.09556 C10H13N5O4 0.52 0.0063
S-Adenosylhomocysteine 10.24 384.12145 C14H20N6O5S 0.56 0.0005
Glycine 9.34 75.03206 C2H5NO2 0.56 0.0091
Adenine 4.32 135.05455 C5H5N5 0.60 0.0015
l-Carnitine 12.08 161.10523 C7H15NO3 0.61 0.0016
(R)-2-Amino-3-hydroxypropanoic acid 9.51 105.04264 C3H7NO3 0.65 0.0102
N-Acetyl-d-galactosamine 4.26 221.08994 C8H15NO6 0.72 0.0009
3-Ketosphinganine 6.29 299.28224 C18H37NO2 0.79 0.0007