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Fig. 5 | Cancer Communications

Fig. 5

From: Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Fig. 5

Enhanced antioxidant capacity in sorafenib-resistant cells. Comparison of the a GSH/GSSG ratio, b glutamine uptake levels and c intracellular l-cysteine levels in the sensitive (BaF3/ITD and MV4-11) and resistant (BaF3/ITD-R and MV4-11-R) cells. d Immunoblotting analysis of major antioxidant enzymes and enzymes in the transsulfuration pathway in BaF3/ITD, BaF3/ITD-R, MV4-11, and MV4-11-R cells. Results are representative of three independent experiments. Bars, means ± SEM. **P < 0.01, ***P < 0.001, vs. sensitive cells. GSH glutathione, GSSG glutathione disulfide

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