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Fig. 4 | Cancer Communications

Fig. 4

From: Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Fig. 4

The sorafenib-resistant cells display reduced proliferation, higher demand for glucose, and decreased NADPH levels. a Cycle distribution analysis of BaF3/ITD, BaF3/ITD-R, MV4-11 and MV4-11-R cells. b Proliferation curves determined by the direct counting of the BaF3/ITD, BaF3/ITD-R, MV4-11 and MV4-11-R cells for 72 h. **P < 0.01, ***P < 0.001. c Proliferation curves of BaF3/ITD and MV4-11 cells with or without glucose in the culture medium. **P < 0.01, ***P < 0.001, vs. cells cultured with glucose in the medium. d Proliferation curves of BaF3/ITD-R and MV4-11-R cells with or without glucose in the culture medium. e,f Comparison of NADPH level and NADPH/NADP+ ratio in sensitive and resistant cells. Bars, mean ± SEM. **P < 0.01, ***P < 0.001, vs. sensitive cells. DT doubling time, NADPH nicotinamide adenine dinucleotide phosphate

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