Variable | PFS | OS | DMFS | LRRFS | LRFS | RRFS | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Age | 0.827 (0.408–1.675) | 0.598 | 1.604 (0.625–4.113) | 0.326 | 0.440 (0.148–1.308) | 0.140 | 0.728 (0.331–1.600) | 0.429 | 0.619 (0.224–1.715) | 0.357 | 1.328 (0.507–3.479) | 0.564 |
Sex | 0.699 (0.336–1.454) | 0.338 | 0.503 (0.164–1.542) | 0.230 | 0.467 (0.148–1.472) | 0.194 | 0.533 (0.237–1.197) | 0.127 | 0.531 (0.189–1.492) | 0.230 | 0.585 (0.211–1.619) | 0.302 |
T stage | 2.739 (1.173–6.397) | 0.020 | 4.114 (1.140–14.847) | 0.031 | 10.722 (2.408–47.740) | 0.002 | 1.536 (0.611–3.861) | 0.361 | 1.433 (0.437–4.702) | 0.553 | 2.606 (0.803–8.465) | 0.111 |
N stage | 2.735 (0.761–9.837) | 0.123 | 2.530 (0.577–11.090) | 0.218 | 9.408 (1.465–60.435) | 0.018 | 1.475 (0.367–5.927) | 0.583 | 2.379 (0.359–15.749) | 0.369 | 2.085 (0.416–10.446) | 0.372 |
Clinical stage | 0.516 (0.214–1.246) | 0.142 | 1.309 (0.421–4.071) | 0.642 | 0.384 (0.095–1.549) | 0.179 | 0.637 (0.266–1.530) | 0.313 | 0.408 (0.120–1.392) | 0.152 | 0.740 (0.244–2.242) | 0.594 |
EBV DNA before first treatment | 1.360 (0.658–2.811) | 0.407 | 0.777 (0.276–2.184) | 0.632 | 1.639 (0.548–4.901) | 0.377 | 1.912 (0.843–4..338) | 0.121 | 1.000 (0.357–2.798) | 0.999 | 3.576 (1.010–12.658) | 0.048 |
Preoperative EBV DNA | 1.546 (0.758–3.151) | 0.231 | 5.535 (1.677–18.268) | 0.005 | 1.898 (0.655–5.499) | 0.238 | 1.571 (0.733–3.365) | 0.245 | 2.622 (0.944–7.286) | 0.064 | 2.804 (1.018–7.727) | 0.046 |
Postoperative pathological result | 5.209 (1.185–22.900) | 0.029 | – | – | 9.265 (1.035–82.935) | 0.047 | 10.175 (1.273–81.320) | 0.029 | 4.158 (0.457–37.820) | 0.206 | – | – |
Treatment for NPC | 1.282 (0.780–2.108) | 0.327 | 1.702 (0.711–4.070) | 0.232 | 2.619 (0.929–7.383) | 0.069 | 1.141 (0.672–1.938) | 0.626 | 0.865 (0.476–1.573) | 0.635 | 2.398 (0.971–5.922) | 0.058 |