Fig. 2
From: Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer
Disrupting the redox homeostasis by inhibition of NADPH-producing enzyme such as MTHFD2 as a novel therapeutic strategy for colorectal cancer. Abbreviations: NADPH, nicotinamide adenine dinucleotide phosphate; NADP+, triphosphopyridine nucleotide; G-6-PD, glucose-6-phosphate dehydrogenase; MTHFD 2, methylenetetrahydrofolate dehydrogenase 2; GSH, reduced glutathione; GSSG, oxidized glutathione; ROS, reactive oxygen species