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Table 1 Clinical characteristics of 416 NSCLC patients treated with EGFR-TKIs
| Variables | Patients | EGFR mutation | EGFR copy number | |||||
|---|---|---|---|---|---|---|---|---|
| n = 416 | Mutant | Wild | FISH (+) | FISH (−) | ||||
| No. | % | n = 169 | n = 247 | P value | n = 167 | n = 249 | P value | |
| Age groups | ||||||||
| ≤ 60 | 264 | 63.5 | 108 (63.9) | 156 (63.2) | 0.918 | 108 (64.7) | 156 (62.7) | 0.680 |
| > 60 | 152 | 36.5 | 61 (36.1) | 91 (36.8) | 59 (35.3) | 93 (37.3) | ||
| Gender | ||||||||
| Male | 253 | 60.8 | 86 (50.9) | 167 (67.6) | < 0.001 | 92 (55.1) | 161 (64.7) | 0.052 |
| Female | 163 | 39.2 | 83 (49.1) | 80 (32.4) | 75 (44.9) | 88 (35.3) | ||
| Smoking status | ||||||||
| Never-smoker | 269 | 64.7 | 129 (76.3) | 140 (56.7) | < 0.001 | 116 (69.5) | 155 (62.2) | 0.142 |
| Smoker | 147 | 35.3 | 40 (23.7) | 107 (43.3) | 51 (30.5) | 94 (37.8) | ||
| Histology | ||||||||
| ADC | 336 | 80.8 | 154 (91.1) | 182 (73.7) | < 0.001 | 138 (82.6) | 198 (79.5) | 0.449 |
| Non-ADC | 80 | 19.2 | 15 (8.9) | 65 (26.3) | 29 (17.4) | 51 (20.5) | ||
| Differentiation | ||||||||
| High to medium | 185 | 44.5 | 92 (54.4) | 93 (37.7) | < 0.001 | 85 (50.9) | 100 (40.2) | 0.035 |
| Low | 231 | 55.5 | 77 (45.6) | 154 (62.3) | 82 (49.1) | 149 (59.8) | ||
| Disease stage | ||||||||
| Recurrent | 128 | 30.8 | 55 (32.5) | 73 (29.6) | 0.127 | 51 (30.5) | 77 (30.9) | 0.926 |
| IIIb | 73 | 17.5 | 22 (13.0) | 51 (20.6) | 28 (16.8) | 45 (18.1) | ||
| IV | 215 | 51.7 | 92 (54.4) | 123 (49.8) | 88 (52.7) | 127 (51.0) | ||
| Clinical response | ||||||||
| CR + PR | 93 | 22.4 | 68 (40.2) | 25 (10.1) | < 0.001 | 53 (31.7) | 40 (16.1) | < 0.001 |
| SD | 158 | 38.0 | 83 (49.1) | 75 (30.4) | 79 (47.3) | 79 (31.7) | ||
| PD | 161 | 38.7 | 14 (8.3) | 147 (59.5) | 32 (19.2) | 129 (51.8) | ||
| Unknown | 4 | 1.0 | 4 (2.4) | 0 (0.0) | 3 (1.8) | 1 (0.4) | ||
| Line of EGFR-TKIs | ||||||||
| First | 104 | 25.0 | 62 (36.7) | 42 (17.0) | < 0.001 | 48 (28.7) | 56 (22.5) | < 0.001 |
| Second | 217 | 52.2 | 107 (63.3) | 110 (44.5) | 97 (58.1) | 120 (48.2) | ||
| Higher | 95 | 22.8 | 0 (0.0) | 95 (38.5) | 22 (13.2) | 73 (29.3) | ||
