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Table 1 Phase I design of dose escalation of induction carbon ion boost for treating GBM and AA

From: Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial

Remarks Boost set Induction carbon ion Boost Cumulative BED* (GyE) EQD2* (GyE)
Dose/Fx (GyE) No. of Fx Total dose (GyE) Tumor (α/β = 10) Brain (α/β = 3) Tumor (α/β = 10) Brain (α/β = 3)
Phase I starting dose 1 3 2 6 79.8 112.0 66.5 67.2
2 3 3 9 83.7 118.0 69.8 70.8
3 4 3 12 88.8 128.0 74.0 76.8
4 5 3 15 94.5 140.0 78.8 84.0
5 6 3 18 100.8 154.0 84.0 92.4
PRT regimen N/A 0 0 0 72.0 100.0 60.0 60.0
  1. GBM glioblastoma, AA anaplastic astrocytoma, BED biological effective dose, EQD2 equivalent dose for a 2 GyE/fraction treatment, α/β alpha/beta ratio, Fx fraction, GyE gray-equivalents
  2. * The dose of proton radiotherapy (60 GyE in 30 fractions) is included in the calculation of cumulative BED and EQD2