Table 1 Phase I design of dose escalation of induction carbon ion boost for treating GBM and AA
Remarks | Boost set | Induction carbon ion Boost | Cumulative BED* (GyE) | EQD2* (GyE) | ||||
|---|---|---|---|---|---|---|---|---|
Dose/Fx (GyE) | No. of Fx | Total dose (GyE) | Tumor (α/β = 10) | Brain (α/β = 3) | Tumor (α/β = 10) | Brain (α/β = 3) | ||
Phase I starting dose | 1 | 3 | 2 | 6 | 79.8 | 112.0 | 66.5 | 67.2 |
2 | 3 | 3 | 9 | 83.7 | 118.0 | 69.8 | 70.8 | |
3 | 4 | 3 | 12 | 88.8 | 128.0 | 74.0 | 76.8 | |
4 | 5 | 3 | 15 | 94.5 | 140.0 | 78.8 | 84.0 | |
5 | 6 | 3 | 18 | 100.8 | 154.0 | 84.0 | 92.4 | |
PRT regimen | N/A | 0 | 0 | 0 | 72.0 | 100.0 | 60.0 | 60.0 |