Clinicopathological features and impact of adjuvant chemotherapy on the long-term survival of patients with multiple gastric cancers: a propensity score matching analysis

Table 3 Univariate and multivariate analysis to determine the prognostic factors for the overall survival in the matched cohort

Parameters	Univariate analysis	P value	Multivariate analysis	P value
Parameters	HR (95% CI)	P value	HR (95% CI)	P value
MGC
Absent	Ref		Ref
Present	1.456 (1.079–1.964)	0.014	1.378 (1.016–1.870)	0.039
Age (years)
≤ 60	Ref		Ref
> 60	1.343 (1.03–1.751)	0.029	1.319 (1.009–1.726)	0.043
cT stage
T1–T3	Ref		Ref
T4	2.862 (2.181–3.755)	< 0.001	0.931 (0.663–1.307)	0.681
cN stage
N0	Ref		Ref
N+	2.592 (1.882–3.568)	< 0.001	1.085 (0.762–1.545)	0.652
Surgical approach
Open	Ref		Ref
Laparoscopic	0.611 (0.458–0.815)	< 0.001	0.777 (0.577–1.048)	0.098
Type of gastrectomy
Total	Ref		Ref
Distal	0.479 (0.328–0.699)	< 0.001	0.794 (0.530–1.187)	0.261
pT stage		< 0.001		< 0.001
T1	Ref		Ref
T2	2.57 (0.996–6.629)	0.051	2.011 (0.760–5.324)	0.159
T3	5.776 (2.620–12.732)	< 0.001	2.996 (1.231–7.292)	0.016
T4a	13.604 (6.384–28.989)	< 0.001	4.944 (1.974–12.383)	0.001
pN stage		< 0.001		< 0.001
N0	Ref		Ref
N1	2.107 (1.122–3.955)	0.02	1.413 (0.704–2.835)	0.330
N2	3.254 (1.887–5.610)	< 0.001	1.667 (0.878–3.164)	0.118
N3	8.778 (5.563–13.85)	< 0.001	3.557 (1.98–6.392)	< 0.001
Tumor size
≤ 5 cm	Ref		Ref
> 5 cm	2.986 (2.304–3.871)	< 0.001	1.314 (0.982–1.758)	0.066
Histological subtype
Differentiated	Ref		Ref
Undifferentiated	1.564 (1.120–2.183)	0.009	1.077 (0.765–1.516)	0.672
Adjuvant chemotherapy^a
No	Ref		Ref
Yes	1.335 (1.025–1.739)	0.032	0.706 (0.535–0.932)	0.014

HR hazard ratio, CI confidence interval, MGC multiple gastric cancers, cT stage clinical tumor stage, cN stage clinical node stage, cN0 clinical node-negative, cN+ clinical node-positive, pT stage pathological tumor stage, pN stage pathological node stage, Ref reference
^aAdjuvant chemotherapy only the matched 547 patients with advanced gastric cancer were analyzed

ISSN: 2523-3548