Skip to main content

Advertisement

Table 3 Univariate and multivariate analysis to determine the prognostic factors for the overall survival in the matched cohort

From: Clinicopathological features and impact of adjuvant chemotherapy on the long-term survival of patients with multiple gastric cancers: a propensity score matching analysis

Parameters Univariate analysis P value Multivariate analysis P value
HR (95% CI) HR (95% CI)
MGC     
 Absent Ref   Ref  
 Present 1.456 (1.079–1.964) 0.014 1.378 (1.016–1.870) 0.039
Age (years)     
 ≤ 60 Ref   Ref  
 > 60 1.343 (1.03–1.751) 0.029 1.319 (1.009–1.726) 0.043
cT stage     
 T1–T3 Ref   Ref  
 T4 2.862 (2.181–3.755) < 0.001 0.931 (0.663–1.307) 0.681
cN stage     
 N0 Ref   Ref  
 N+ 2.592 (1.882–3.568) < 0.001 1.085 (0.762–1.545) 0.652
Surgical approach     
 Open Ref   Ref  
 Laparoscopic 0.611 (0.458–0.815) < 0.001 0.777 (0.577–1.048) 0.098
Type of gastrectomy     
 Total Ref   Ref  
 Distal 0.479 (0.328–0.699) < 0.001 0.794 (0.530–1.187) 0.261
pT stage   < 0.001   < 0.001
 T1 Ref   Ref  
 T2 2.57 (0.996–6.629) 0.051 2.011 (0.760–5.324) 0.159
 T3 5.776 (2.620–12.732) < 0.001 2.996 (1.231–7.292) 0.016
 T4a 13.604 (6.384–28.989) < 0.001 4.944 (1.974–12.383) 0.001
pN stage   < 0.001   < 0.001
 N0 Ref   Ref  
 N1 2.107 (1.122–3.955) 0.02 1.413 (0.704–2.835) 0.330
 N2 3.254 (1.887–5.610) < 0.001 1.667 (0.878–3.164) 0.118
 N3 8.778 (5.563–13.85) < 0.001 3.557 (1.98–6.392) < 0.001
Tumor size     
 ≤ 5 cm Ref   Ref  
 > 5 cm 2.986 (2.304–3.871) < 0.001 1.314 (0.982–1.758) 0.066
Histological subtype     
 Differentiated Ref   Ref  
 Undifferentiated 1.564 (1.120–2.183) 0.009 1.077 (0.765–1.516) 0.672
Adjuvant chemotherapya     
 No Ref   Ref  
 Yes 1.335 (1.025–1.739) 0.032 0.706 (0.535–0.932) 0.014
  1. HR hazard ratio, CI confidence interval, MGC multiple gastric cancers, cT stage clinical tumor stage, cN stage clinical node stage, cN0 clinical node-negative, cN+ clinical node-positive, pT stage pathological tumor stage, pN stage pathological node stage, Ref reference
  2. aAdjuvant chemotherapy only the matched 547 patients with advanced gastric cancer were analyzed