The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study

Table 5 Associations of 25 SNPs of 10 genes with ECG abnormalities

Gene	SNP	Nucleotide change	MAF	HWE P value	χ ²	Association P value
ATM	rs1003623	C/T	0.49	0.00	1.57	0.46
	rs227060	C/T	0.32	0.50	0.85	0.65
	rs228589	A/T	0.46	0.00	0.82	0.57
	rs664143	C/T	0.37	0.93	0.20	0.91
	rs664677	A/C/T	0.35	0.23	0.95	0.62
ATG5	rs473543	C/T	0.39	0.51	1.42	0.49
ATG5	rs3761796	A/G	0.07	0.25	2.06	0.36
ATG7	rs2594971	C/T	0.50	0.01	0.37	0.83
	rs111595248	C/T	0.05	0.48	0.33	0.56
	rs4684789	G/T	0.42	0.34	0.50	0.78
ATG12	rs1058600	A/G	0.42	0.96	1.77	0.41
ATG12	rs5870670	Del/T	0.39	–	1.37	0.24
STMN1	rs182455	C/T	0.36	0.35	2.84	0.24
ATG13	rs13448	C/T	0.40	0.20	3.25	0.20
ATG13	rs10838611	C/G/T	0.38	0.08	20.19	0.00
MAP1LC3A	rs4911429	A/G	0.36	0.75	1.17	0.56
MAP1LC3A	rs6088521	A/C/G/T	0.35	0.43	0.67	0.72
MAP1LC3B	rs9903	C/T	0.19	0.38	0.55	0.76
	rs35227715	C/G	0.25	0.12	0.53	0.77
	rs7865	C/G/T	0.31	0.00	0.57	0.45
	rs16944733	A/C/T	0.20	0.00	1.58	0.45
CASP3	rs1049216	C/T	0.40	0.58	1.75	0.42
	rs12108497	C/G/T	0.39	0.25	0.97	0.61
	rs2720376	C/T	0.46	0.25	0.46	0.79
CRYAB	rs14133	C/G	0.24	0.05	6.31	0.10

HWE Hardy–Weinberg equilibrium, MAF minor allele frequency, ATM ataxia telangiectasia mutated, ATG autophagy-related, MAP1LC microtubule-associated protein 1 light chain, CASP caspase, CRYAB crystallin alpha B, STMN1 stathmin 1

ISSN: 2523-3548