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Table 5 Associations of 25 SNPs of 10 genes with ECG abnormalities

From: The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study

Gene SNP Nucleotide change MAF HWE P value χ 2 Association P value
ATM rs1003623 C/T 0.49 0.00 1.57 0.46
rs227060 C/T 0.32 0.50 0.85 0.65
rs228589 A/T 0.46 0.00 0.82 0.57
rs664143 C/T 0.37 0.93 0.20 0.91
rs664677 A/C/T 0.35 0.23 0.95 0.62
ATG5 rs473543 C/T 0.39 0.51 1.42 0.49
rs3761796 A/G 0.07 0.25 2.06 0.36
ATG7 rs2594971 C/T 0.50 0.01 0.37 0.83
rs111595248 C/T 0.05 0.48 0.33 0.56
rs4684789 G/T 0.42 0.34 0.50 0.78
ATG12 rs1058600 A/G 0.42 0.96 1.77 0.41
rs5870670 Del/T 0.39 1.37 0.24
STMN1 rs182455 C/T 0.36 0.35 2.84 0.24
ATG13 rs13448 C/T 0.40 0.20 3.25 0.20
rs10838611 C/G/T 0.38 0.08 20.19 0.00
MAP1LC3A rs4911429 A/G 0.36 0.75 1.17 0.56
rs6088521 A/C/G/T 0.35 0.43 0.67 0.72
MAP1LC3B rs9903 C/T 0.19 0.38 0.55 0.76
rs35227715 C/G 0.25 0.12 0.53 0.77
rs7865 C/G/T 0.31 0.00 0.57 0.45
rs16944733 A/C/T 0.20 0.00 1.58 0.45
CASP3 rs1049216 C/T 0.40 0.58 1.75 0.42
rs12108497 C/G/T 0.39 0.25 0.97 0.61
rs2720376 C/T 0.46 0.25 0.46 0.79
CRYAB rs14133 C/G 0.24 0.05 6.31 0.10
  1. HWE Hardy–Weinberg equilibrium, MAF minor allele frequency, ATM ataxia telangiectasia mutated, ATG autophagy-related, MAP1LC microtubule-associated protein 1 light chain, CASP caspase, CRYAB crystallin alpha B, STMN1 stathmin 1