Regimen | Time point | |||||||
---|---|---|---|---|---|---|---|---|
Baseline | Cycle 1 | Cycle 2 | Cycle 3 | Cycle 4 | Cycle 5 | Cycle 6 | Cycle 7 | |
Overall | ||||||||
Ā Cases (%) | 142 (96.6) | 85 (57.8) | 90 (61.2) | 87 (59.2) | 85 (57.8) | 73 (49.7) | 60 (40.8) | 34 (23.1) |
Ā Heart rate (bpm, meanāĀ±āSD) | 75.3āĀ±ā11.4 | 79.4āĀ±ā11.8 | 80.6āĀ±ā12.3 | 79.8āĀ±ā12.2 | 79.0āĀ±ā13.4 | 82.6āĀ±ā12.2 | 82.7āĀ±ā13.3 | 80.7āĀ±ā12.0 |
Ā P value | Ref | <ā0.001 | <ā0.001 | <ā0.001 | <ā0.001 | <ā0.001 | <ā0.001 | 0.003 |
Anthracyclines | ||||||||
Ā Cases (%) | 87 (97.8) | 57 (64.0) | 58 (65.2) | 56 (62.9) | 54 (60.7) | 45 (50.6) | 41 (46.1) | 33 (37.1) |
Ā Heart rate (bpm, meanāĀ±āSD) | 74.8āĀ±ā11.1 | 79.7āĀ±ā11.7 | 80.1āĀ±ā11.5 | 80.5āĀ±ā11.8 | 79.7āĀ±ā14.9 | 81.4āĀ±ā11.3 | 82.7āĀ±ā12.2 | 80.7āĀ±ā12.1 |
Ā P value | Ref | 0.001 | <ā0.001 | <ā0.001 | 0.008 | <ā0.001 | <ā0.001 | 0.004 |
Cyclophosphamide | ||||||||
Ā Cases (%) | 80 (98.8) | 50 (61.7) | 49 (60.5) | 49 (60.5) | 44 (54.3) | 36 (44.4) | 39 (48.1) | 30 (37.0) |
Ā Heart rate (bpm, meanāĀ±āSD) | 73.5āĀ±ā11.2 | 77.4āĀ±ā12.0 | 78.7āĀ±ā12.7 | 79.9āĀ±ā13.1 | 78.2āĀ±ā10.1 | 78.9āĀ±ā11.8 | 81.3āĀ±ā13.5 | 80.2āĀ±ā12.1 |
Ā P value | Ref | 0.004 | <ā0.001 | <ā0.001 | <ā0.001 | <ā0.001 | <ā0.001 | 0.001 |
Paclitaxel | ||||||||
Ā Cases (%) | 60 (96.8) | 37 (59.7) | 39 (62.9) | 39 (62.9) | 43 (69.4) | 28 (45.2) | 28 (45.2) | 18 (29.0) |
Ā Heart rate (bpm, meanāĀ±āSD) | 74.1āĀ±ā10.0 | 80.6āĀ±ā12.1 | 77.8āĀ±ā10.9 | 79.8āĀ±ā10.5 | 81.2āĀ±ā9.0 | 82.0āĀ±ā10.5 | 84.4āĀ±ā14.2 | 81.9āĀ±ā12.7 |
Ā P value | Ref | <ā0.001 | <ā0.001 | 0.002 | <ā0.001 | <ā0.001 | 0.002 | 0.086 |
Docetaxel | ||||||||
Ā Cases (%) | 56 (94.9) | 35 (59.3) | 39 (66.1) | 36 (61.0) | 34 (57.6) | 36 (61.0) | 24 (40.7) | 14 (23.7) |
Ā Heart rate (bpm, meanāĀ±āSD) | 76.4āĀ±ā13.2 | 78.9āĀ±ā12.3 | 83.3āĀ±ā14.0 | 80.4āĀ±ā14.9 | 79.0āĀ±ā12.2 | 83.4āĀ±ā13.9 | 80.3āĀ±ā13.5 | 79.6āĀ±ā12.2 |
Ā P value | Ref | 0.137 | 0.001 | 0.037 | 0.036 | 0.004 | 0.231 | 0.004 |
Carboplatin | ||||||||
Ā Cases (%) | 40 (93.0) | 20 (46.51) | 25 (58.1) | 23 (53.5) | 25 (58.1) | 26 (60.5) | 14 (32.6) | NA |
Ā Heart rate (bpm, meanāĀ±āSD) | 76.1āĀ±ā11.6 | 78.3āĀ±ā9.2 | 81.6āĀ±ā11.3 | 77.3āĀ±ā9.9 | 79.0āĀ±ā9.1 | 85.8āĀ±ā11.9 | 86.0āĀ±ā14.5 | NA |
Ā P value | Ref | 0.442 | 0.023 | 0.690 | 0.034 | 0.001 | 0.157 | NA |