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TableĀ 2 Heart rates of TNBC patients after cycles of chemotherapy

From: The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study

Regimen

Time point

Baseline

Cycle 1

Cycle 2

Cycle 3

Cycle 4

Cycle 5

Cycle 6

Cycle 7

Overall

Ā Cases (%)

142 (96.6)

85 (57.8)

90 (61.2)

87 (59.2)

85 (57.8)

73 (49.7)

60 (40.8)

34 (23.1)

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

75.3ā€‰Ā±ā€‰11.4

79.4ā€‰Ā±ā€‰11.8

80.6ā€‰Ā±ā€‰12.3

79.8ā€‰Ā±ā€‰12.2

79.0ā€‰Ā±ā€‰13.4

82.6ā€‰Ā±ā€‰12.2

82.7ā€‰Ā±ā€‰13.3

80.7ā€‰Ā±ā€‰12.0

Ā P value

Ref

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

0.003

Anthracyclines

Ā Cases (%)

87 (97.8)

57 (64.0)

58 (65.2)

56 (62.9)

54 (60.7)

45 (50.6)

41 (46.1)

33 (37.1)

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

74.8ā€‰Ā±ā€‰11.1

79.7ā€‰Ā±ā€‰11.7

80.1ā€‰Ā±ā€‰11.5

80.5ā€‰Ā±ā€‰11.8

79.7ā€‰Ā±ā€‰14.9

81.4ā€‰Ā±ā€‰11.3

82.7ā€‰Ā±ā€‰12.2

80.7ā€‰Ā±ā€‰12.1

Ā P value

Ref

0.001

<ā€‰0.001

<ā€‰0.001

0.008

<ā€‰0.001

<ā€‰0.001

0.004

Cyclophosphamide

Ā Cases (%)

80 (98.8)

50 (61.7)

49 (60.5)

49 (60.5)

44 (54.3)

36 (44.4)

39 (48.1)

30 (37.0)

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

73.5ā€‰Ā±ā€‰11.2

77.4ā€‰Ā±ā€‰12.0

78.7ā€‰Ā±ā€‰12.7

79.9ā€‰Ā±ā€‰13.1

78.2ā€‰Ā±ā€‰10.1

78.9ā€‰Ā±ā€‰11.8

81.3ā€‰Ā±ā€‰13.5

80.2ā€‰Ā±ā€‰12.1

Ā P value

Ref

0.004

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

<ā€‰0.001

0.001

Paclitaxel

Ā Cases (%)

60 (96.8)

37 (59.7)

39 (62.9)

39 (62.9)

43 (69.4)

28 (45.2)

28 (45.2)

18 (29.0)

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

74.1ā€‰Ā±ā€‰10.0

80.6ā€‰Ā±ā€‰12.1

77.8ā€‰Ā±ā€‰10.9

79.8ā€‰Ā±ā€‰10.5

81.2ā€‰Ā±ā€‰9.0

82.0ā€‰Ā±ā€‰10.5

84.4ā€‰Ā±ā€‰14.2

81.9ā€‰Ā±ā€‰12.7

Ā P value

Ref

<ā€‰0.001

<ā€‰0.001

0.002

<ā€‰0.001

<ā€‰0.001

0.002

0.086

Docetaxel

Ā Cases (%)

56 (94.9)

35 (59.3)

39 (66.1)

36 (61.0)

34 (57.6)

36 (61.0)

24 (40.7)

14 (23.7)

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

76.4ā€‰Ā±ā€‰13.2

78.9ā€‰Ā±ā€‰12.3

83.3ā€‰Ā±ā€‰14.0

80.4ā€‰Ā±ā€‰14.9

79.0ā€‰Ā±ā€‰12.2

83.4ā€‰Ā±ā€‰13.9

80.3ā€‰Ā±ā€‰13.5

79.6ā€‰Ā±ā€‰12.2

Ā P value

Ref

0.137

0.001

0.037

0.036

0.004

0.231

0.004

Carboplatin

Ā Cases (%)

40 (93.0)

20 (46.51)

25 (58.1)

23 (53.5)

25 (58.1)

26 (60.5)

14 (32.6)

NA

Ā Heart rate (bpm, meanā€‰Ā±ā€‰SD)

76.1ā€‰Ā±ā€‰11.6

78.3ā€‰Ā±ā€‰9.2

81.6ā€‰Ā±ā€‰11.3

77.3ā€‰Ā±ā€‰9.9

79.0ā€‰Ā±ā€‰9.1

85.8ā€‰Ā±ā€‰11.9

86.0ā€‰Ā±ā€‰14.5

NA

Ā P value

Ref

0.442

0.023

0.690

0.034

0.001

0.157

NA

  1. All data are compared with baseline values. NA, not applicable (platinum-based chemotherapy was used for only 4ā€“6 cycles)