Fig. 3From: The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial–mesenchymal transition, and immune responseComparison between the DSRCT mutational profile and mutational signatures from Catalogue Of Somatic Mutations In Cancer (COSMIC). a Observed mutational profile of the aggregated list of the 137 somatic mutations categorized according to the 96 possible tri-nucleotide variations. The fraction of mutations found in each trinucleotide context is displayed. b Reconstruction of the observed DSRCT profile according to the 30 COSMIC mutational signatures; known COSMIC signatures which gave the major contribution (weights) are reported at the top of the panel. c Differences between the observed and the reconstructed mutational profiles; the mean error is reported at the top of the panelBack to article page