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Fig. 3 | Cancer Communications

Fig. 3

From: The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial–mesenchymal transition, and immune response

Fig. 3

Comparison between the DSRCT mutational profile and mutational signatures from Catalogue Of Somatic Mutations In Cancer (COSMIC). a Observed mutational profile of the aggregated list of the 137 somatic mutations categorized according to the 96 possible tri-nucleotide variations. The fraction of mutations found in each trinucleotide context is displayed. b Reconstruction of the observed DSRCT profile according to the 30 COSMIC mutational signatures; known COSMIC signatures which gave the major contribution (weights) are reported at the top of the panel. c Differences between the observed and the reconstructed mutational profiles; the mean error is reported at the top of the panel

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