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Table 1 Associations between the clinical characteristics and the re-epithelialization of the nasopharyngeal defects for patients with postradiation nasopharyngeal necrosis who underwent radical necrectomy followed by reconstruction using posterior pedicle nasal septum and floor mucoperiosteum flap (NSFF)

From: A curative-intent endoscopic surgery for postradiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma

Clinical characteristic Total [cases (%)] Re-epithelialization [cases (%)] Univariate analysis Multivariate analysis
Survived Necrotized P value OR (95% CI) P value OR (95% CI)
Total 72 51 (70.8) 21 (29.2)     
Gender
 Female 20 (27.8) 11 (21.6) 9 (42.9)     
 Male 52 (72.2) 40 (78.4) 12 (57.1) 0.072 2.727 (0.915–8.127) 0.778 1.328 (0.185–9.533)
Age (years)
 < 51 32 (44.4) 21 (41.2) 11 (52.4)     
 ≥ 51 40 (55.6) 30 (58.8) 10 (47.6) 0.386 0.636 (0.229–1.768)   
Cycles of radiotherapy
 One 50 (69.4) 40 (78.4) 10 (47.6)     
 Two 22 (30.6) 11 (21.6) 11 (52.4) 0.012 4.000 (1.351–11.845) 0.046 7.254 (1.035–50.821)
Necrosis-free interval
 Acute necrosis 17 (23.6) 14 (27.5) 3 (14.3)     
 Chronic necrosis 55 (76.4) 37 (72.5) 18 (85.7) 0.240 2.270 (0.578–8.919)   
Carotid artery exposure
 Yes 25 (34.7) 19 (37.3) 6 (28.6)     
 No 47 (65.3) 32 (62.7) 15 (71.4) 0.483 0.674 (0.223–2.032)   
Osteoradionecrosis
 Yes 51 (70.8) 35 (68.6) 16 (76.2)     
 No 21 (29.2) 16 (31.4) 5 (23.8) 0.522 1.463 (0.456–4.692)   
Postoperative pathological result
 Negative 52 (72.2) 42 (82.4) 10 (47.6)     
 Positive 20 (27.8) 9 (17.6) 11 (52.4) 0.004 5.133 (1.677–15.714) 0.004 34.087 (3.168–366.746)
Status of the NSFF flap
 Survived 56 (77.8) 49 (96.1) 7 (33.3)     
 Necrotized 16 (22.2) 2 (3.9) 14 (66.7) < 0.001 49.000 (9.133–262.904) < 0.001 261.179 (17.176–3971.599)
  1. OR odds ratio, CI confidence interval, NSFF posterior pedicle nasal septum, and floor mucoperiosteum flap