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Fig. 5 | Cancer Communications

Fig. 5

From: Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study

Fig. 5

Target neck lymph node lesion in a 39-year-old man (staged with T4N2M0) treated with famitinib (20 mg) and CCRT: clinical example of stable disease (SD) according to RECIST (version 1.1.). a Contrast-enhanced ultrasound with a strong vascularized lesion (arrow) and corresponding time intensity curve at baseline. b The metastatic neck lymph node lesion was evident in the axial T2-weighted MRI image at baseline (arrow). c Fourteen days after the onset of famitinib alone treatment, D-CEUS revealed an enhancement in tumour vascularity density with a drastic increase of tumour perfusion parameters, as shown by the contrast enhancement pattern and corresponding time-intensity curve. d The longest diameter of the metastatic neck lymph node lesion did not change in the axial T2-weighted MRI image at D15 (arrow). e Time-intensity curves of tumour enhancement at baseline (blue curve), on D8 (red curve) and on D15 (green curve). It was possible to observe an increase in the maximum enhancement and higher area under the enhancement curve early after treatment. f The metastatic neck lymph node lesion disappeared after the completion of CCRT and famitinib treatment (arrow), but the patients exhibited thoracic vertebrae metastasis (g, arrow) 5 months after complete treatment

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