External validity of a prognostic nomogram for locoregionally advanced nasopharyngeal carcinoma based on the 8th edition of the AJCC/UICC staging system: a retrospective cohort study

Table 3 Multivariate analysis of patients from the Sun Yat-sen University Cancer Center

	HR (95% CI)	P-value
Factors included in the best predictive model
The 8th AJCC/UICC N-classification	1.968 (1.480–2.617)	< 0.001
Age (per year increase)	1.055 (1.032–1.079)	< 0.001
GTVp (per cc increase)	1.016 (1.009–1.023)	< 0.001
LDH (per IU/L increase)	1.005 (1.000–1.010)	0.033
BMI (per kg/m² increase)	0.921 (0.854–0.995)	0.036
Factors absent from the best predictive model
The 8th AJCC/UICC T-classification	1.076 (0.720–1.607)	0.721
EBV DNA (< 10³/10³–10⁴/10⁴–10⁵/10⁵–10⁶/≥ 10⁶)	1.033 (0.826–1.293)	0.774
Sex	0.759 (0.430–1.337)	0.339
Histology	0.714 (0.305–1.671)	0.437

HR hazard ratio, CI confidence interval, AJCC American Joint Committee on Cancer, UICC Union for International Cancer Control, GTVp gross primary tumor volume, LDH lactate dehydrogenase, BMI body mass index

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