Table 3 Frequency, detailed combination patterns, progression-free survival, overall survival and response to first-generation TKIs of compound EGFR mutations

Double common

5 (4.7)

25.0%

10.1 ± 2.4

24.2 ± 8.2

 19Del + L858R

5

19 and 21

3PR, 1SD, 1PD

4.9–12

13.1–25.6

Common + rare

11 (10.4)

45.5%

10.5 ± 3.9

Not reached

 19Del + L861Q

2

19 and 21

1PR, 1SD

11.9–14.4

26.5–41.2

 L858R + S720P

1

21 and 18

PD

2.1

2.1

 L858R + K757R

1

21 and 19

PR

9.0

8.7

 L858R + I744 M

1

21 and 19

PR

17.6

41.2

 L858R + S768I

3

21 and 20

1PR, 1PD, 1SD

1.8–6.2

4.0–12.5

 L858R + R776H

1

21 and 20

PR

10.5

12.6

 L858R + L858Q

1

21 and 21

NE

1

3

 L858R + L833V

1

21 and 21

SD

5.0

15.9

Common + T790M

69 (65.1)

56.5%

10.3 ± 0.6

Not reached

 19Del + T790M

43

19 and 20

27PR, 12SD, 2 PD, 2NE

0.6–40.7

0.2–88.5

 L858R + T790M

26

21 and 20

12PR, 10SD, 3PD, 1NE

0.9–24.1

1.2–56.6

Rare + rare

13 (12.3)

38.5%

6.5 ± 1.3

Not reached

 G719C + S768I

1

18 and 20

PR

6.5

13.2

 G719S + S768I

2

18 and 20

1PR, 1SD

1–8.0

2.0–8.4

 G719S + L858Q

1

18 and 21

SD

6.4

29.3

 G719X + S768I

3

18 and 20

2PR, 1SD

2.0–18

2.0–44.0

 G719X + L858Q

3

18 and 21

1SD, 1PD, 1NE

0.3–27.3

2.3–29.2

 G719S + E709A

1

18 and 18

PR

4.1

4.1

 G719S + L858Q

1

18 and 21

SD

6.4

29.3

 S768I + V774M

1

20 and 20

PD

2.0

13.8

Rare + T790M

8 (7.5%)

37.5%

5.4 ± 2.5

23.8 ± 1.5

 G719X + T790M

1

18 and 20

PR

11.1

55.6

 D761Y + T790M

2

19 and 20

2PD

1.1–5.5

1.1–8.5

 L858Q + T790M

5

21 and 20

2PR, 1SD, 2PD

1.4–20.6

18–88.3