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Fig. 5 | Cancer Communications

Fig. 5

From: Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4

Fig. 5

Overexpression of AIB1 enhances lung adenocarcinoma A549 cell metastasis mediated by CXCR4 in vivo. a Left: representative lungs showing metastatic nodules originating from A549-vector, A549-AIB1, and A549-AIB1 + CXCR4-shRNA cells injected with Balb/c nude mice. Right: number of metastatic nodules formed in the lungs of mice 6 weeks after tail vein injection of A549-vector, A549-AIB1, and A549-AIB1 + CXCR4-shRNA cells (eight mice per group; *P < 0.05; independent Student’s t test). b Representative hematoxylin and eosin (H&E) staining and IHC staining of AIB1 and CXCR4 in lung metastatic tumors originating from A549-vector, A549-AIB1, and A549-AIB1 + CXCR4-shRNA cells injected with Balb/c nude mice

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