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Fig. 3 | Cancer Communications

Fig. 3

From: Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4

Fig. 3

Overexpression of AIB1 enhances lung adenocarcinoma A549 cell migration and invasion in vitro. a Left: Western blotting reveals that ectopic expression of AIB1 was substantially increased in A549-AIB1 cells compared with that in A549-vector cells (upper panel); right: representative results of wound-healing assays demonstrate that A549-AIB1 cells had higher motility than A549-vector cells. The numbers of migrating cells are shown in the left bottom panel. Data are the mean ± SE of three independent experiments; **P < 0.001 by Student’s t test. b Ectopic overexpression of AIB1 enhanced A549 cell invasion in a Transwell assay. Data are the mean ± SE of three independent experiments; *P < 0.05 by Student’s t test

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