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Fig. 2 | Cancer Communications

Fig. 2

From: Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4

Fig. 2

Silencing of AIB1 by RNA interference inhibits lung adenocarcinoma cell migration and invasion in vitro. a Left: the levels of AIB1 expression in 5 lung adenocarcinoma cell lines by Western blotting analysis; right: Western blotting reveals that AIB1 was efficiently knocked down by the treatment with AIB1-shRNA1 and AIB1-shRNA2. b Wound-healing assays show that AIB1-silenced H1975 and H1993 cells had lower motility than control cells. c Cell invasion was evaluated using a Matrigel invasion chamber. Silencing of AIB1 decreased H1975 and H1993 cell invasive capacity. The numbers of invaded cells in the shAIB1 and control groups are shown in the right panel. Data are the mean ± standard error (SE) of three independent experiments; *P < 0.05, **P < 0.01 versus cells transfected with shC by Student’s t test

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