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Fig. 1 | Cancer Communications

Fig. 1

From: Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4

Fig. 1

Amplified in breast cancer 1 (AIB1) expression in lung adenocarcinoma tissues. Immunohistochemical (IHC) staining of AIB1 in normal lung tissues (a) and the primary lesions of localized (n = 61, mean positive rate of AIB1 expression is 19.7%) (b), regional (n = 76, mean positive rate of AIB1 expression is 40.3%) (c), and metastatic (n = 30, mean positive rate of AIB1 expression is 70.5%) (d) lung adenocarcinoma tissues. e The box plots demonstrate the range of AIB1 expression within each group (non-tumor, localized tumor, regional tumor, and metastatic tumor). f Receiver operating characteristic (ROC) curve of AIB1 in lung adenocarcinomas with regional lymph node metastasis compared to non-regional metastatic lung adenocarcinomas. Blue line: ROC curve, green line: reference line. g ROC curve of AIB1 in metastatic lung adenocarcinomas compared to non-metastatic lung adenocarcinomas. Blue line: ROC curve, green line: reference line. h Overall survival curve according to AIB1 expression level for 167 lung adenocarcinoma patients

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