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Table 4 Best fit multivariate models for the 2492 Asian breast cancer patients treated with breast-conserving therapy (1989–2012)

From: Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy

Clinicopathologic characteristics Overall survival Breast cancer-specific survival Breast cancer-free interval Time to local recurrence
Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value Hazard ratio (95% CI) P value
No. of events/no. of patients 98/1988   54/2120   182/1988   64/2120  
Age at diagnosis 25.21 [(age/10)−2 − 0.04] + 0.06 [(age/10)2 − 25]a < 0.001 0.95 (0.92–0.98) 0.001 13.14 [(age/10)−2 − 0.04]a < 0.001 0.95 (0.93–0.98) < 0.001
Tumor size 1.21 (0.99–1.46) 0.064 Not included   1.15 (1.00–1.32) 0.050 Not included  
Grade   < 0.001 Not included    < 0.001 Not included  
 1 1     1    
 2 4.06 (1.59–10.38)     3.38 (1.78–6.41)    
 3 4.94 (1.90–12.84)     4.08 (2.12–7.86)    
No. of positive nodes 1.05 (1.01–1.09) 0.031 Not included   1.06 (1.03–1.09) 0.001 Not included  
Histologic subtype   0.024   0.002   0.007   0.002
 Luminal A/B 1   1   1   1  
 HER2 enriched 1.02 (0.50–2.12)   0.80 (0.24–2.64)   1.39 (0.85–2.28)   3.42 (1.82–6.41)  
 Basal 1.99 (1.22–3.25)   2.94 (1.64–5.28)   1.85 (1.27–2.69)   1.61 (0.82–3.15)  
  1. aWhere age was significantly non-linear, the fractional polynomial function was presented instead of the hazard ratio. Age was scaled by a factor of 10 and centered on 50 years in these models. Where the number of events was insufficient to include all the covariates in the model, only age and histologic subtype were included