Table 4 Best fit multivariate models for the 2492 Asian breast cancer patients treated with breast-conserving therapy (1989–2012)
Clinicopathologic characteristics | Overall survival | Breast cancer-specific survival | Breast cancer-free interval | Time to local recurrence | ||||
|---|---|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
No. of events/no. of patients | 98/1988 | 54/2120 | 182/1988 | 64/2120 | ||||
Age at diagnosis | 25.21 [(age/10)−2 − 0.04] + 0.06 [(age/10)2 − 25]a | < 0.001 | 0.95 (0.92–0.98) | 0.001 | 13.14 [(age/10)−2 − 0.04]a | < 0.001 | 0.95 (0.93–0.98) | < 0.001 |
Tumor size | 1.21 (0.99–1.46) | 0.064 | Not included | 1.15 (1.00–1.32) | 0.050 | Not included | ||
Grade | < 0.001 | Not included | < 0.001 | Not included | ||||
1 | 1 | 1 | ||||||
2 | 4.06 (1.59–10.38) | 3.38 (1.78–6.41) | ||||||
3 | 4.94 (1.90–12.84) | 4.08 (2.12–7.86) | ||||||
No. of positive nodes | 1.05 (1.01–1.09) | 0.031 | Not included | 1.06 (1.03–1.09) | 0.001 | Not included | ||
Histologic subtype | 0.024 | 0.002 | 0.007 | 0.002 | ||||
Luminal A/B | 1 | 1 | 1 | 1 | ||||
HER2 enriched | 1.02 (0.50–2.12) | 0.80 (0.24–2.64) | 1.39 (0.85–2.28) | 3.42 (1.82–6.41) | ||||
Basal | 1.99 (1.22–3.25) | 2.94 (1.64–5.28) | 1.85 (1.27–2.69) | 1.61 (0.82–3.15) | ||||