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Fig. 4 | Cancer Communications

Fig. 4

From: Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo

Fig. 4

Inhibitory effects of azithromycin and TRAIL on HCT-116 xenografts in nude mice. a The body weight of HCT-116 xenograft-bearing nude mice (n = 6). b The antitumor effect of azithromycin and/or TRAIL on the growth of HCT-116 xenografts in nude mice (n = 6). #P < 0.05 compared with the control. c The tumor weight of the four groups. #P < 0.05 vs. the control, *P < 0.05 vs. azithromycin. d Representative photographs of the excised HCT-116 tumors from four groups. e Detection of Ki-67 in HCT-116 xenografts by immunohistochemistry. Cells with brownish yellow particles were considered as Ki-67 positive. Ki-67% was equal to the percentage of Ki-67 positive area and total area. ##P < 0.01 vs. the control, **P < 0.01 vs. TRAIL. AZM represents azithromycin

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