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Fig. 1 | Cancer Communications

Fig. 1

From: Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo

Fig. 1

Azithromycin inhibits cell proliferation of colon cancer cell lines. a The viability of SW620, DiFi, SW480 and HCT-116 cells after 48 h-of treatment with azithromycin at various concentrations was assessed with the SRB assay. b The proliferative activity of HCT-116 and SW480 cells after treatment with azithromycin (5–225 µmol/L) for 24–72 h was assessed by the SRB assay. The survival rate was calculated as a ratio to the control group (untreated cells). Values represent the mean ± SD of three independent samples. Each experiment was repeated three times. c DR4/5 expression, Akt and MAPK pathways of colon cancer cell lines. HCT-116, SW480, SW620 and DiFi cells not receiving any treatment were used as controls. AZM represents azithromycin

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