Fig. 2

Cancer cells coordinate nutrient status with the methylation of histone and DNA. Cancer cells alter methylation of histones (a) and DNA (b) in response to nutrient status. SAM S-adenosyl methionine, SAH S-adenyl homocysteine, KMT lysine methyltransferase, PRMT protein arginine methyltransferase, LSD lysine-specific demethylase, DNMT DNA methyltransferase, TCA tricarboxylic acid cycle, TET ten-eleven translocation methylcytosine dioxygenase