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Fig. 6 | Cancer Communications

Fig. 6

From: Boron delivery agents for neutron capture therapy of cancer

Fig. 6

Boron cluster containing redox nanoparticles (BNP) for tumor BNCT. a Scheme for preparing boron cluster containing redox nanoparticles. b Biodistribution of BNP in tumor-bearing mice. c Tumor growth curves of tumor-bearing mice after 40-min thermal neutron irradiation (1.3–1.7 × 1012 neutron/cm2). Mice with a mean original tumor volume of 140 mm3 received BNP at doses of 15 and 5 mg 10B/kg. Mice administered BPA–fructose complex at a dose of 40 mg 10B/kg were used as the positive control. Mice administered boron cluster containing redox nanoparticles with the same amount of nitroxide radical as in the BNP-treated group at a dose of 15 mg 10B/kg and PBS with and without (PBS-C) irradiation were used as negative controls (n = 3, mean ± SD, *P < 0.01, **P < 0.005, Student’s t test). Reproduced with permission. Copyright 2016, Elsevier [117]

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