Fig. 6

Boron cluster containing redox nanoparticles (BNP) for tumor BNCT. a Scheme for preparing boron cluster containing redox nanoparticles. b Biodistribution of BNP in tumor-bearing mice. c Tumor growth curves of tumor-bearing mice after 40-min thermal neutron irradiation (1.3–1.7 × 10¹² neutron/cm²). Mice with a mean original tumor volume of 140 mm³ received BNP at doses of 15 and 5 mg ¹⁰B/kg. Mice administered BPA–fructose complex at a dose of 40 mg ¹⁰B/kg were used as the positive control. Mice administered boron cluster containing redox nanoparticles with the same amount of nitroxide radical as in the BNP-treated group at a dose of 15 mg ¹⁰B/kg and PBS with and without (PBS-C) irradiation were used as negative controls (n = 3, mean ± SD, *P < 0.01, **P < 0.005, Student’s t test). Reproduced with permission. Copyright 2016, Elsevier [117]