Fig. 3

BSH-dendrimer conjugates for BNCT. a Conjugation scheme for the linkage of a boron-containing dendrimer to cetuximab; b Cellular binding of cetuximab. Varying amounts (5 − 100 ng) of ¹²⁵I-cetuximab were incubated at 4 °C for 90 min with cells expressing wild-type EGF receptors (F98_EGFR) (black up-pointing triangle), mutant EGFRvIII receptors (F98_EGFRvIII) (black circle), and receptor-negative parental cells (F98_WT) (white square). c Boron neutron capture therapy effect of BSH-polymer conjugation on colon 26 subcutaneous tumor-bearing BALB/c mice. Reproduced with permission. Copyright 2004, ACS [150]