Fig. 5

Macroscopic and pathologic images of a 69-year-old woman with extramammary Paget’s disease (EMPD). a External appearance before boron neutron capture therapy (BNCT): the labia and the vulva, presented as a pinkish, partially depigmented, and eczematous patch with irregular border in the mons pubic area (arrows). b Microscopic findings: pagetoid cells infiltrated all levels of the epidermis and slightly invaded the upper dermis. c External appearance after BNCT: absorbed doses following BNCT were 6.4 Gy-Eq to the normal skin and 20 Gy-Eq to the tumor. The EMPD lesion showed a complete response with depigmentation. She died of heart disease with no evidence of recurrence or adverse effects 3.2 years following BNCT