|
Characteristics
|
Low-risk patients
|
High-risk patients
|
|---|
|
Long interval
|
Short interval
|
P
|
Long interval
|
Short interval
|
P
|
|---|
|
(n = 390)
|
(n = 475) (%)
|
(n = 149) (%)
|
(n = 213) (%)
|
|---|
|
Gender
| | |
0.926
| | |
0.001
|
|
Male
|
344 (88.2)
|
418 (88)
| |
123 (82.6)
|
199 (93.4)
| |
|
Female
|
46 (11.8)
|
57 (12.0)
| |
26 (17.4)
|
14 (6.6)
| |
|
Age (years)
|
52 (14)
|
50 (19)
|
0.072
|
51 (17)
|
49 (17)
|
0.292
|
|
Tumor number
| | |
0.273
| | |
0.891
|
|
Solitary
|
359 (92.1)
|
427 (89.9)
| |
92 (61.7)
|
130 (61)
| |
|
Multiple
|
31 (7.9)
|
48 (10.1)
| |
57 (38.3)
|
83 (39)
| |
|
Tumor size (cm)
| | |
0.458
| | |
0.674
|
|
> 5
|
60 (15.4)
|
82 (17.3)
| |
109 (73.2)
|
160 (75.1)
| |
|
≤ 5
|
330 (84.6)
|
393 (82.7)
| |
40 (26.8)
|
53 (24.9)
| |
|
Tumor size (cm)
|
3.5 (2.0)
|
3.5 (2.3)
|
0.288
|
8 (5.0)
|
8 (4.8)
|
0.916
|
|
Tumor location
| | |
0.054
| | |
0.287
|
|
Central
|
96 (24.6)
|
145 (30.5)
| |
16 (10.7)
|
16 (7.5)
| |
|
Subcapsular
|
294 (75.4)
|
330 (69.5)
| |
133 (89.3)
|
197 (92.5)
| |
|
Tumor differentiation
| | |
0.393
| | |
0.761
|
|
Poor
|
45 (11.5)
|
64 (13.5)
| |
20 (13.4)
|
31 (14.6)
| |
|
Moderate and well
|
345 (88.5)
|
411 (86.5)
| |
129 (86.6)
|
182 (85.4)
| |
|
Tumor MVI
| | |
0.627
| | |
0.126
|
|
Yes
|
27 (6.9)
|
29 (6.1)
| |
95 (63.8)
|
152 (71.4)
| |
|
No
|
363 (93.1)
|
446 (93.9)
| |
54 (36.2)
|
61 (28.6)
| |
|
BCLC stage
| | |
0.604
| | |
0.238
|
|
0/A
|
380 (97.4)
|
460 (96.8)
| |
110 (73.8)
|
145 (68.1)
| |
|
B
|
10 (2.6)
|
15 (3.2)
| |
39 (26.2)
|
68 (31.9)
| |
|
Etiology
| | |
0.901
| | |
0.694
|
|
Non-hepatitis
|
37 (9.5)
|
47 (9.9)
| |
18 (12.1)
|
22 (10.3)
| |
|
HBV
|
347 (89)
|
420 (88.4)
| |
129 (86.6)
|
189 (88.7)
| |
|
HCV
|
6 (1.5)
|
8 (1.7)
| |
2 (1.3)
|
2 (0.9)
| |
|
WBC (109/L)
|
5.8 (1.9)
|
5.9 (2.3)
|
0.189
|
6.0 (2)
|
6.5 (2.8)
|
0.014
|
|
RBC (109/L)
|
4.73 (0.7)
|
4.8 (0.7)
|
0.123
|
4.75 (0.7)
|
4.81 (0.7)
|
0.460
|
|
Hemoglobin (g/L)
|
147 (16.4)
|
146.7 (18)
|
0.922
|
144 (22)
|
145.9 (20.9)
|
0.392
|
|
PLT (109/L)
|
161.3 (79.3)
|
162 (72)
|
0.526
|
192 (88)
|
189 (77)
|
0.643
|
|
ALT (U/L)
|
36.9 (27.2)
|
36.1 (23.7)
|
0.857
|
37 (26.7)
|
39.8 (29.6)
|
0.196
|
|
AST (U/L)
|
31.2 (16.8)
|
31.5 (14.8)
|
0.882
|
39.4 (25.4)
|
40.7 (25.2)
|
0.774
|
|
ALB (g/L)
|
42.8 (4.6)
|
43.1 (4.5)
|
0.083
|
42.2 (4.7)
|
43 (4.4)
|
0.074
|
|
TBIL (μmol/L)
|
12.9 (5.9)
|
13.4 (6.5)
|
0.129
|
12.2 (6.2)
|
12.7 (5.8)
|
0.502
|
|
PT (s)
|
11.7 (1.3)
|
11.6 (1.2)
|
0.590
|
11.6 (1.2)
|
11.6 (1.1)
|
0.615
|
|
ALBI grade
| | |
0.720
| | |
0.432
|
|
I
|
335 (85.9)
|
412 (86.7)
| |
116 (77.9)
|
173 (81.2)
| |
|
II
|
55 (14.1)
|
63 (13.3)
| |
33 (22.1)
|
40 (18.8)
| |
|
AFP (ng/mL)
| | |
0.289
| | |
0.905
|
|
> 200
|
111 (28.5)
|
151 (31.8)
| |
66 (44.3)
|
93 (43.7)
| |
|
≤ 200
|
279 (71.5)
|
324 (68.2)
| |
83 (55.7)
|
120 (56.3)
| |
|
Cirrhosis
| | |
0.957
| | |
0.296
|
|
Yes
|
288 (73.8)
|
350 (73.7)
| |
95 (63.8)
|
147 (69)
| |
|
No
|
102 (26.2)
|
125 (26.3)
| |
54 (36.2)
|
66 (31)
| |
|
Resection margin (cm)
|
1 (1.5)
|
1 (1.15)
|
0.526
|
1 (1.5)
|
1 (1.5)
|
0.894
|
|
Operative blood loss (ml)
| | |
0.691
| | |
0.173
|
|
> 400
|
45 (11.5)
|
59 (12.4)
| |
52 (34.9)
|
60 (28.2)
| |
|
≤ 400
|
345 (88.5)
|
416 (87.6)
| |
97 (65.1)
|
153 (71.8)
| |
- Values are presented as the median (interquartile range) or n (%)
- MVI microvascular invasion, BCLC stage Barcelona clinic liver cancer stage, HBV hepatitis B virus, HCV hepatitis C virus, WBC white blood cell, RBC red blood cell, PLT platelet, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB albumin, TBIL total bilirubin, PT prothrombin time, ALBI albumin-bilirubin, AFP alpha-fetoprotein
