Table 1 Baseline characteristics of 2126 patients who underwent resection for hepatocellular carcinoma stratified by risk of recurrence
| Characteristics |
Low-risk patients (n = 1425) (%) |
High-risk patients (n = 701) (%) | P |
|---|---|---|---|
| Gender | 0.509 | ||
| Male | 1244 (87.3) | 619 (88.3) | |
| Female | 181 (12.7) | 82 (11.7) | |
| Age (years) | 52 (17) | 50 (18) | 0.001 |
| Tumor number | < 0.001 | ||
| Solitary | 137 (9.6) | 293 (41.8) | |
| Multiple | 1288 (90.4) | 408 (58.2) | |
| Tumor size (cm) | < 0.001 | ||
| > 5 | 246 (17.3) | 532 (75.9) | |
| ≤ 5 | 1179 (82.7) | 169 (24.1) | |
| Tumor size (cm) | 3.5 (2.2) | 8 (4.8) | < 0.001 |
| Tumor location | < 0.001 | ||
| Central | 389 (27.3) | 54 (7.7) | |
| Subcapsular | 1036 (72.7) | 647 (92.3) | |
| Tumor differentiation | 0.040 | ||
| Poor | 194 (13.6) | 119 (17) | |
| Moderate and well | 1231 (86.4) | 582 (83) | |
| Tumor MVI | < 0.001 | ||
| Yes | 87 (6.1) | 498 (71) | |
| No | 1338 (93.9) | 203 (29) | |
| BCLC stage | < 0.001 | ||
| 0/A | 1380 (96.8) | 482 (68.8) | |
| B | 45 (3.2) | 219 (31.2) | |
| Etiology | 0.646 | ||
| Non-hepatitis | 137 (9.6) | 70 (10) | |
| HBV | 1267 (88.9) | 624 (89) | |
| HCV | 21 (1.5) | 7 (1) | |
| WBC (109/L) | 5.8 (2.1) | 6.3 (2.5) | < 0.001 |
| RBC (109/L) | 4.75 (0.7) | 4.8 (0.8) | 0.010 |
| Hemoglobin (g/L) | 146.5 (17.5) | 146 (21.0) | 0.360 |
| PLT (109/L) | 161 (77) | 189.5 (92) | < 0.001 |
| ALT (U/L) | 35.7 (25.6) | 38.4 (27.5) | 0.002 |
| AST (U/L) | 31 (16.3) | 39.6 (26.6) | < 0.001 |
| ALB (g/L) | 43 (4.6) | 42.3 (4.8) | < 0.001 |
| TBIL (μmol/L) | 13.4 (6.6) | 12.5 (6.2) | 0.003 |
| PT (s) | 11.7 (1.3) | 11.7 (1.3) | 0.684 |
| ALBI grade | < 0.001 | ||
| I | 1216 (85.3) | 550 (78.5) | |
| II | 209 (14.7) | 151 (21.5) | |
| AFP (ng/mL) | < 0.001 | ||
| > 200 | 468 (32.8) | 332 (47.4) | |
| ≤ 200 | 957 (67.2) | 369 (52.6) | |
| Cirrhosis | 0.092 | ||
| Yes | 1075 (75.4) | 505 (72) | |
| No | 350 (24.6) | 196 (28) | |
| Resection margin (cm) | 1 (1.5) | 1 (1.0) | < 0.001 |
| Operative blood loss (mL) | < 0.001 | ||
| > 400 | 173 (12.1) | 214 (30.5) | |
| ≤ 400 | 1252 (87.9) | 487 (69.5) | |