Table 1 Demographic and clinicopathologic variables of 6753 patients with advanced gastric cancer in the training and validation sets
Variables | SYSUCC training set (n = 2169) | CMU validation set (n = 2353) | TJMU validation set (n = 2231) | P value |
|---|---|---|---|---|
Age (years)a | 59 (50–66) | 60 (52–68) | 59 (50–68) | < 0.001 |
Sex | 0.049 | |||
Male | 1510 (69.6) | 1714 (72.8) | 1576 (70.6) | |
Female | 659 (30.4) | 639 (27.2) | 655 (29.4) | |
Tumor location | < 0.001 | |||
Antrum | 813 (37.5) | 1260 (53.5) | 787 (35.3) | |
Body | 376 (17.3) | 317 (13.5) | 288 (12.9) | |
Cardia/fundus | 894 (41.2) | 644 (27.4) | 746 (33.4) | |
Whole stomach | 86 (4.0) | 132 (5.6) | 410 (18.4) | |
Tumor size (cm)a | 4.5 (3.0–6.0) | 5.0 (3.5–6.5) | 5.0 (3.5–7.0) | < 0.001 |
Lauren classification | < 0.001 | |||
Intestinal | 766 (35.3) | 1166 (49.6) | 859 (38.5) | |
Diffuse | 1403 (64.7) | 1187 (50.4) | 1372 (61.5) | |
Lymphatic/venous invasion | < 0.001 | |||
No | 1917 (88.4) | 1556 (66.1) | NA | |
Yes | 252 (11.6) | 797 (33.9) | NA | |
T category | < 0.001 | |||
T2 | 298 (13.7) | 933 (39.7) | 195 (8.7) | |
T3 | 472 (21.8) | 602 (25.6) | 186 (8.3) | |
T4a | 1224 (56.4) | 672 (28.6) | 1673 (75.0) | |
T4b | 175 (8.1) | 146 (6.2) | 177 (7.9) | |
No. of metastatic lymph nodesa | 3 (0–8) | 3 (0–8) | 2 (0–7) | < 0.001 |
No. of lymph nodes dissecteda | 21 (13–29) | 27 (18–36) | 17 (11–24) | < 0.001 |
Metastatic lymph node ratioa | 0.17 (0–0.43) | 0.11 (0–0.33) | 0.15 (0–0.46) | < 0.001 |