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Table 1 Potential driver mutations and shared mutations between brain tumor and lung metastasis

From: Somatic mutation landscape of a meningioma and its pulmonary metastasis

Mutation AA change Exonic function Brain AF Lung AF Intogena REVELb MCAPc
NF2 L125fs Frameshift deletion 0.29 0.16 TIER-1   
YBX3 P164fs Frameshift deletion 0.28 0.088    
SETD1B S1366S Synonymous SNV 0.28 0.20 Passenger   
CDT1 G164D Nonsynonymous SNV 0.27 0.14 Not-protein-affecting 0.037 0.011
OR5AU1 D71V Nonsynonymous SNV 0.27 0.11 Not-protein-affecting 0.20 0.011
NLGN2 H485D Nonsynonymous SNV 0.27 0.20 Passenger 0.74 0.12
MPI R272R Synonymous SNV 0.27 0.12 Passenger   
DGKZ A885A Synonymous SNV 0.072 0.064 Passenger   
KRT86 A334A Synonymous SNV 0.051 0.057 Passenger   
ANKS4B F234F Synonymous SNV 0.021 0.085 Passenger   
VPS13B T3820 delinsMFS Nonframeshift insertion 0.021 0.053 Passenger   
ANKS4B F234fs Frameshift insertion 0.017 0.056 Passenger   
PTPRC R183fs Frameshift insertion 0.014 ND TIER-2   
TXNIP A275fs Frameshift insertion 0.013 ND TIER-1   
  1. AF allele frequency, ND not detected
  2. aPotential of gene function categorized by Intogen
  3. bREVEL score predicting functional impact of amino acid change to the protein
  4. cMCAP score predicting functional impact of amino acid change to the protein