Somatic mutation landscape of a meningioma and its pulmonary metastasis

Cancer Communications

Table 1 Potential driver mutations and shared mutations between brain tumor and lung metastasis

Mutation	AA change	Exonic function	Brain AF	Lung AF	Intogen^a	REVEL^b	MCAP^c
NF2	L125fs	Frameshift deletion	0.29	0.16	TIER-1
YBX3	P164fs	Frameshift deletion	0.28	0.088
SETD1B	S1366S	Synonymous SNV	0.28	0.20	Passenger
CDT1	G164D	Nonsynonymous SNV	0.27	0.14	Not-protein-affecting	0.037	0.011
OR5AU1	D71V	Nonsynonymous SNV	0.27	0.11	Not-protein-affecting	0.20	0.011
NLGN2	H485D	Nonsynonymous SNV	0.27	0.20	Passenger	0.74	0.12
MPI	R272R	Synonymous SNV	0.27	0.12	Passenger
DGKZ	A885A	Synonymous SNV	0.072	0.064	Passenger
KRT86	A334A	Synonymous SNV	0.051	0.057	Passenger
ANKS4B	F234F	Synonymous SNV	0.021	0.085	Passenger
VPS13B	T3820 delinsMFS	Nonframeshift insertion	0.021	0.053	Passenger
ANKS4B	F234fs	Frameshift insertion	0.017	0.056	Passenger
PTPRC	R183fs	Frameshift insertion	0.014	ND	TIER-2
TXNIP	A275fs	Frameshift insertion	0.013	ND	TIER-1

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