Table 1 Summary of 13 common core pathways associated with pancreatic cancer in six GEO microarray datasets
Pathway ID | Pathway name | GSE71989 | GSE15471 | GSE16515 | GSE32676 | GSE41368 | GSE28735 | Total degree | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Outd | Ind | Outd | Ind | Outd | Ind | Outd | Ind | Outd | Ind | Outd | Ind | |||
05200 | Pathway in cancer | 28 | 0 | 21 | 0 | 15 | 0 | 23 | 0 | 21 | 0 | 8 | 0 | 116 |
04115 | P53 signaling pathway | 2 | 16 | 2 | 12 | 2 | 6 | 1 | 13 | 1 | 11 | 0 | 3 | 69 |
04510 | Focal adhesion | 8 | 7 | 7 | 5 | 6 | 4 | 6 | 5 | 7 | 6 | 3 | 4 | 68 |
04060 | Cytokine-cytokine receptor interaction | 0 | 16 | 0 | 14 | 0 | 8 | 0 | 9 | 0 | 13 | 0 | 4 | 64 |
04810 | Regulation of actin cytoskeleton | 3 | 9 | 3 | 8 | 3 | 6 | 3 | 7 | 3 | 9 | 1 | 2 | 57 |
00010 | Glycolysis/Gluconeogenesis | 2 | 14 | 0 | 6 | 3 | 11 | 0 | 4 | 2 | 10 | 1 | 3 | 56 |
05322 | Systemic lupus erythematosus | 8 | 0 | 7 | 0 | 6 | 0 | 6 | 0 | 8 | 0 | 2 | 0 | 37 |
05219 | Bladder cancer | 6 | 1 | 5 | 1 | 5 | 1 | 5 | 1 | 4 | 1 | 1 | 1 | 32 |
05222 | Small cell lung cancer | 5 | 1 | 5 | 1 | 5 | 1 | 4 | 1 | 4 | 1 | 3 | 1 | 32 |
04610 | Complement and coagulation cascades | 1 | 7 | 0 | 6 | 0 | 2 | 0 | 2 | 1 | 6 | 0 | 1 | 26 |
04512 | ECM-receptor interaction | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 1 | 3 | 24 |
04360 | Axon guidance | 3 | 0 | 3 | 0 | 3 | 0 | 3 | 0 | 3 | 0 | 2 | 0 | 17 |
05211 | Renal cell carcinoma | 4 | 1 | 2 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 0 | 1 | 17 |