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Fig. 6 | Cancer Communications

Fig. 6

From: Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma

Fig. 6

CKS2 promotes pancreatic cancer cell proliferation. a Significant pathways enriched in genes whose expression profile matches that of CKS2, based on DAVID software. b CKS2 mRNA levels in pancreatic cancer tissues and paired normal tissues from 102 patients with PDAC at our hospital, based on real-time PCR analysis. Results are mean ± SEM. *P < 0.05. c Western blotting of CKS2 in PDAC cell lines BxPC-3 and CFPAC-1, as well as in non-cancer pancreatic duct epithelial cell line HPDE6-C7. d Western blotting of CKS2 in PDAC (T) and paired normal tissues (N). Representative results of 20 pairs of clinical specimens are shown. e CKS2 knockdown in BxPC-3 and CFPAC-1 cells. Levels of mRNAs were determined by qRT-PCR. Results are mean ± SEM from three independent experiments. f CKS2 knockdown substantially reduced proliferation of BxPC-3 and CFPAC-1 cells, as determined using the CCK-8 assay. Results are mean ± SEM from three experiments, each conducted with six replicates of each sample. ***P < 0.001 vs. control

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