Fig. 3

Computed tomography (CT) scans and pathology for patient CTC15063_{EGFR L858R, T790M} and the patient-derived xenograft tumors. CT chest scans of patient CTC15063_{EGFR L858R, T790M} were recorded 4.5 years after undergoing surgical resection and subsequent adjuvant chemotherapy (navelbine plus cisplatin). a Disease recurrence was found in a CT scan as a right sub-pleural nodule on 2012-3-12; b disease progression 26 months after erlotinib treatment was visible in a CT scan as malignant pleural effusion on 2014-6-27; c CT reexamination after 2 months of osimertinib treatment showed stable disease on 2015-10-8. Pathology (H&E staining) of tumor biopsy from d patient CTC15063_{EGFR L858R, T790M} and e a xenograft CTC15063_{EGFR L858R, T790M} tumor after osimertinib treatment