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Table 4 Maximum toxicity grade in patients treated with TPF versus PF after matching

From: Effect of induction chemotherapy with cisplatin, fluorouracil, with or without taxane on locoregionally advanced nasopharyngeal carcinoma: a retrospective, propensity score-matched analysis

Adverse event PF group [cases (%)] TPF group [cases (%)] P value
Grade 0–2 Grade 3–4 Grade 0–2 Grade 3–4
Neutropenia 207 (70.4) 87 (29.6) 176 (59.9) 118 (40.1) 0.009
Anemia 275 (93.5) 19 (6.5) 286 (97.3) 8 (2.7) 0.047
Thrombocytopenia 268 (91.2) 26 (8.8) 284 (96.6) 10 (3.4) 0.009
Liver injury 291 (99.0) 3 (1.0) 292 (99.3) 2 (0.7) 1.000
Kidney injury 294 (100) 0 (0) 294 (100) 0 (0) 1.000
Nausea/vomiting 114 (38.8) 180 (61.2) 151 (51.4) 143 (48.6) 0.003
Any of the above 109 (37.0) 185 (63.0) 83 (28.2) 211 (71.8) 0.028
  1. TPF taxane, cisplatin and 5-fluorouracil, PF cisplatin and 5-fluorouracil. Adverse events were graded according to the National Cancer Institute Common Toxicity Criteria, version 4.0